Cortisol-dependent stress effects on cell distribution in healthy individuals and individuals suffering from chronic adrenal insufficiency
| Autor: | Joachim Feldkamp, Kenneth P. Pitts, Ashley M. Geiger, Clemens Kirschbaum, Jutta M. Wolf |
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| Rok vydání: | 2015 |
| Předmět: |
Cortisol secretion
Adult Male medicine.medical_specialty genetic structures Epinephrine Hydrocortisone medicine.drug_class Immunology Article Behavioral Neuroscience Norepinephrine Cell Movement Internal medicine Adrenal insufficiency medicine Trier social stress test Humans Lymphocytes Endocrine and Autonomic Systems Adrenal cortex Middle Aged medicine.disease medicine.anatomical_structure Endocrinology Mineralocorticoid Chronic Disease Female sense organs Psychology Glucocorticoid hormones hormone substitutes and hormone antagonists Stress Psychological medicine.drug Adrenal Insufficiency |
| Zdroj: | Brain, behavior, and immunity. 50 |
| ISSN: | 1090-2139 |
| Popis: | Chronic adrenal insufficiency (CAI) is characterized by a lack of glucocorticoid and mineralocorticoid production due to destroyed adrenal cortex cells. However, elevated cortisol secretion is thought to be a central part in a well-orchestrated immune response to stress. This raises the question to what extent lack of cortisol in CAI affects stress-related changes in immune processes. To address this question, 28 CAI patients (20 females) and 18 healthy individuals (11 females) (age: 44.3 ± 8.4 years) were exposed to a psychosocial stress test (Trier Social Stress Test: TSST). Half the patients received a 0.03 mg/kg body weight injection of hydrocortisone (HC) post-TSST to mimic a healthy cortisol stress response. Catecholamines and immune cell composition were assessed in peripheral blood and free cortisol measured in saliva collected before and repeatedly after TSST. CAI patients showed norepinephrine (NE) stress responses similar to healthy participants, however, epinephrine (E) as well as cortisol levels were significantly lower. HC treatment post-TSST resulted in cortisol increases comparable to those observed in healthy participants (interaction effects--NE: F=1.05, p=.41; E: F=2.56, p=.045; cortisol: F=13.28, p |
| Databáze: | OpenAIRE |
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