Evaluation of Oxidant-Antioxidant Status of Fluvoxamine on Human Lymphocyte Cell Culture
| Autor: | Suzan Muratoglu Severcan, Mostafa Norizadeh Tazehkand, Zehra Safi Oz, Çınar Severcan, Aslihan Gurbuz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Human lymphocyte
Antioxidant business.industry Basic Sciences medicine.medical_treatment Serotonin reuptake inhibitor Temel Bilimler Oxidant antioxidant Fluvoxamine Pharmacology medicine.disease_cause Cell culture medicine Antidepressant business Oxidative stress Human lymphocyte cell culture Total oxidant status (TOS) Total antioxidant status (TAS) Oxidative stress index (OSI) Fluvoxamine medicine.drug |
| Zdroj: | Volume: 8, Issue: 1 79-83 Hittite Journal of Science and Engineering |
| ISSN: | 2148-4171 |
| Popis: | Depression is one of the prevalent psychiatric diseases in Turkey and the world. Fluvoxamine is a strong selective serotonin reuptake inhibitor (SSRI) that is used as an antidepressant. No study investigating the doses of Fluvoxamine treatment that may lead to a disruption in the oxidant-antioxidant balance on the cellular level in addition to its beneficial effects has been found in the literature. For this purpose, by creating Fluvoxamine application groups at the doses of 7.5, 15, 30 and 60 μM and durations of 24 and 48 hours on human lymphocyte cell cultures, we investigated the total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI). According to the results of the study, the TOS levels of all dose groups increased significantly in the 24- and 48-hour applications (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|