Supplementary Tables S1-S4 from IRS2 Copy Number Gain, KRAS and BRAF Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines

Autor: Joan M. Carboni, Jeffrey Jackson, Friedrich G. Finckenstein, Tai W. Wong, Rolf-Peter Ryseck, Craig Fairchild, Zhenhao Qi, Dharmesh Patel, John Cogswell, Warren Hurlburt, Karen A. Reeves, Stephen Hillerman, Ann Greer, Han Chang, Fei Huang
Rok vydání: 2023
DOI: 10.1158/1535-7163.22503652.v1
Popis: Supplementary Tables S1-S4. Supplementary Table S1: Association of gene mutations, IRS2 copy number gain, and gene expression level with in vitro sensitivity to BMS-754807 in 60 CRC cell lines. Supplementary Table S2: The relationship between KRAS, BRAF and PIK3CA mutation status and the sensitivity of BMS-754807 in 60 CRC cell lines. Supplementary Table S3: Statistical analyses identified CNV of 197 genes located on chromosome 13 significantly associated with in vitro sensitivity to BMS-754807 in 60 CRC cell lines. Supplementary Table S4: Data mining indicate IRS2 CNG is more prevalent in CRC than in other tumor types.
Databáze: OpenAIRE