Cells Involved in the Immune Response
| Autor: | M. Richter, R. Haasz |
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| Rok vydání: | 1971 |
| Předmět: | |
| Zdroj: | Pathobiology. 37:425-435 |
| ISSN: | 1423-0291 1015-2008 |
| DOI: | 10.1159/000162348 |
| Popis: | It has been shown that extirpation of the thymus, the spleen, and the SAPP organs (appendix, sacculus rotundus and Peyer’s patches) in the normal adult rabbit does not affect the capacity of the rabbit to mount a humoral immune response to either particulate (SRBC or HRBC) or soluble protein (HSA or BGG or OA) antigens. Since it has previously been shown that the bone marrow does not constitute the organ capable of providing the host with the antibody-forming cells (AFC), it is concluded that no single lymphoid organ in the immunologically mature rabbit at the time of immunization constitutes the source of virgin AFC or serves as a necessary site of maturation of the AFC. Furthermore, the spleen, thymus and SAPP organs do not appear to possess any hormonal function with respect to the maintenance of immunocompetent cells. It is assumed that no single lymph node or the unorganized lymphoid cell accumulations or infiltrations would possess this unique role. It is, therefore, postulated that either all the lymphoid organs in the mature, adult rabbit possess virgin AFC or that the AFC represents a transient stage of morphological development of a potentially immunocompetent population of lymphocytes. Evidence has been presented that these cells, ontogenetically, probably arise in the gut-associated (SAPP) lymphoid organs and disseminate and infiltrate the other lymphoid organs either prenatally or in the early postnatal period. |
| Databáze: | OpenAIRE |
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