Patterns of Failure and Survival Trends Of 720 Patients with Stage I Nasopharyngeal Carcinoma Diagnosed from 1990-2012: A Large-scale Retrospective Cohort Study
| Autor: | Hai Qiang Mai, Chao Nan Qian, Xiang Guo, Chong Zhao, Qing Nan Tang, Shan Shan Guo, Tong Yu Lu, Dong Hua Luo, Qi Yu Zhong, Bo Lin Chen, Meng Sha Zou, Ling Guo, Shao Yan Guo, Li Ting Liu, Yang Li, Rui Sun, Qiu Yan Chen, Lin Quan Tang, Wen Hui Chen, Hao Yuan Mo, Mu Sheng Zeng |
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| Rok vydání: | 2018 |
| Předmět: |
Patterns of failure
Oncology medicine.medical_specialty Radiotherapy business.industry medicine.medical_treatment Retrospective cohort study Patient survival Subgroup analysis Prognosis medicine.disease 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Internal medicine medicine Progression-free survival Stage I Nasopharyngeal Carcinoma business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Objectives: To evaluate the patterns of failure and survival trends of patients with stage I nasopharyngeal carcinoma (NPC) treated with radiotherapy alone over the last 20 years. Materials and Methods: A retrospective cohort study was conducted on 720 patients with stage I NPC who were treated with curative two-dimensional radiotherapy (2DRT), three-dimensional conformal radiotherapy (3DRT), or intensity-modulated radiotherapy (IMRT) between January 1990 and December 2012. The patients were categorized into four calendar periods (1990-1996, 1997-2002, 2003-2007, and 2008-2012) and four age subgroups (18-39, 40-49, 50-59, and >60). We computed overall survival (OS), progression free survival (PFS), locoregional relapse free survival (LRFS) and distant metastasis free survival (DMFS) as measures of patient survival. Results: After a median follow-up period of 105 months (range 1-280 months), we observed the increasing trends in survival and disease control. The 3-, 5-, and 7-year OS rates increased from 97.0%, 86.7%, and 81.7% in the first calendar period (1990-1996) to 100%, 99.3%, and 98.0% in the last calendar period (2008-2012), respectively (P |
| Databáze: | OpenAIRE |
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