Effects of concomitant use of fibroblast growth factor (FGF)-2 with beta-tricalcium phosphate (β-TCP) on the beagle dog 1-wall periodontal defect model
| Autor: | Jun Anzai, Shinya Murakami, Masahiro Kitamura, Toshie Nagayasu, Akio Terashima, Takenori Nozaki, Taiji Asano |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Calcium Phosphates
Periodontium Molar Pathology medicine.medical_specialty Biophysics Junctional epithelium Biochemistry Beagle Dogs Animals Regeneration Periodontal fiber Medicine Cementum Periodontitis Molecular Biology business.industry Cell Biology Anatomy medicine.disease Disease Models Animal medicine.anatomical_structure Clinical attachment loss Female Fibroblast Growth Factor 2 business |
| Zdroj: | Biochemical and Biophysical Research Communications. 403:345-350 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2010.11.032 |
| Popis: | The effects of concomitant use of fibroblast growth factor-2 (FGF-2) and beta-tricalcium phosphate (β-TCP) on periodontal regeneration were investigated in the beagle dog 1-wall periodontal defect model. One-wall periodontal defects were created in the mesial portion of both sides of the mandibular first molars, and 0.3% FGF-2 plus β-TCP or β-TCP alone was administered. Radiographic evaluation was performed at 0, 3, and 6 weeks. At 6 weeks, the periodontium with the defect site was removed and histologically analyzed. Radiographic findings showed that co-administration of FGF-2 significantly increased bone mineral contents of the defect sites compared with β-TCP alone. Histologic analysis revealed that the length of the regenerated periodontal ligament, the cementum, distance to the junctional epithelium, new bone height, and area of newly formed bone were significantly increased in the FGF-2 group. No abnormal inflammatory response or ankylosis was observed in either group. These findings indicate the efficacy of concomitant use of FGF-2 and β-TCP as an osteoconductive material for periodontal regeneration following severe destruction by progressive periodontitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect