The acute effect of black tea consumption on resistance artery endothelial function in healthy subjects. A randomized controlled trial

Autor: David M. de Bresser, Matthew J. Rowson, Arno Greyling, Thalijn L C Wolters, Dick H. J. Thijssen, Niels P. Riksen, Theo Mulder, Maria T. E. Hopman, Sean H.P.P. Roerink
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Endocrinology
Diabetes and Metabolism
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Vasodilation
Blood Pressure
030204 cardiovascular system & hematology
Gastroenterology
RC1200
0302 clinical medicine
Ingestion
Nutrition and Dietetics
Cross-Over Studies
Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16]
food and beverages
Arteries
Middle Aged
Plethysmography
medicine.anatomical_structure
Cholesterol
Female
Sodium nitroprusside
medicine.drug
Artery
Nitroprusside
medicine.medical_specialty
Clinical nutrition
Placebo
Arginine
03 medical and health sciences
Forearm
Double-Blind Method
Internal medicine
medicine
Humans
Triglycerides
Aged
Nutrition
Flavonoids
030109 nutrition & dietetics
Dose-Response Relationship
Drug
Tea
business.industry
Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6]
Hemodynamics
Acetylcholine
Blood pressure
Physical therapy
Endothelium
Vascular
business
Zdroj: Clinical nutrition ESPEN, 23, pp. 41-47
Clinical nutrition ESPEN, 23, 41-47
ISSN: 2405-4577
DOI: 10.1016/j.clnesp.2017.10.011
Popis: Contains fulltext : 187840.pdf (Publisher’s version ) (Closed access) BACKGROUND & AIMS: Black tea is a main source of flavonoids in the Western diet and has been associated with reduced risk for cardiovascular disease, possibly through lowering blood pressure. These effects may be mediated through improving endothelial function of resistance arteries. The aim of this study was therefore to examine the acute impact of black tea on forearm resistance artery endothelial function in healthy, normotensive middle-aged subjects. METHODS: Twenty middle-aged men and women (age-range 45-75 years) were recruited into a double-blind, randomized, placebo-controlled crossover intervention study. Forearm resistance artery blood flow (FBF, measured using venous occlusion plethysmography) in response to incremental doses of acetylcholine, sodium nitroprusside and L-N(G)-monomethyl arginine were determined 2 h after consumption of either black tea containing approximately 400 mg flavonoids (equivalent to 2-3 cups of tea) or a taste- and color-matched placebo. RESULTS: The mean FBF-response to acetylcholine after tea consumption was 23% higher compared to the response after placebo (95% CI: -20%, +88%), but this difference did not reach statistical significance (P = 0.32). No significant differences in the FBF-responses to sodium nitroprusside and L-N(G)-monomethyl arginine were found between the tea and placebo interventions (P = 0.96 and 0.74, respectively). Correcting FBF for changes in blood pressure did not alter the outcomes. CONCLUSIONS: We found no evidence that acute intake of black tea significantly altered endothelium-dependent vasodilation of forearm resistance arteries in healthy middle-aged subjects. Interventions with a longer duration of tea ingestion are required to further explore the (long-term) impact of tea flavonoids on blood pressure regulatory mechanisms. This trial was registered at clinicaltrials.gov as NCT02328339. 01 februari 2018
Databáze: OpenAIRE
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