Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development
| Autor: | Nina Kramer, Markus Hengstschläger, Angelika Walzl, Helmut Dolznig, Martin Scherzer, Christine Unger |
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| Rok vydání: | 2014 |
| Předmět: |
Cell Culture Techniques
Drug Evaluation Preclinical Pharmaceutical Science Cancer Antineoplastic Agents 3d model Pharmacology Biology Bioinformatics medicine.disease Models Biological Drug development In vivo Drug Design Neoplasms Anti cancer drugs Lack of efficacy Drug response medicine Animals Humans Tumor stroma |
| Zdroj: | Advanced Drug Delivery Reviews. :50-67 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2014.10.015 |
| Popis: | Anti-cancer drug development is inefficient, mostly due to lack of efficacy in human patients. The high fail rate is partly due to the lack of predictive models or the inadequate use of existing preclinical test systems. However, progress has been made and preclinical models were improved or newly developed, which all account for basic features of solid cancers, three-dimensionality and heterotypic cell interaction. Here we give an overview of available in vivo and in vitro models of cancer, which meet the criteria of being 3D and mirroring human tumor-stroma interactions. We only focus on drug response models without touching models for pharmacokinetic and dynamic, toxicity or delivery aspects. |
| Databáze: | OpenAIRE |
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