Direct halosulfenylation of benzo[b]furans: a metal-free synthesis of 3-halo-2-thiobenzo[b]furans

Autor:	Dayun Huang, Yinlin Shao, Jiuxi Chen, Tianxing Cheng, Qianqian Zhen
Rok vydání:	2018
Předmět:	010405 organic chemistry Organic Chemistry Substituent 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Furan Halogen Physical and Theoretical Chemistry
Zdroj:	Organic & Biomolecular Chemistry. 16:9204-9210
ISSN:	1477-0539 1477-0520
DOI:	10.1039/c8ob02680g
Popis:	The first example of the direct halosulfenylation of benzo[b]furans with commercially available disulfides and N-halosuccinimides has been achieved, providing an efficient metal-free synthetic pathway to access diverse 3-halo-2-thiobenzo[b]furans in moderate to excellent yields. In particular, a halogen (e.g., bromo or iodo) substituent on the benzo[b]furan ring is amenable for further synthetic elaborations thereby broadening the diversity of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faec344729ea30f02a89debce399125e https://doi.org/10.1039/c8ob02680g Zobrazit plný text záznamu