High Prevalence of Leptospira spp. in Rodents in an Urban Setting in Madagascar
| Autor: | Minoarisoa Rajerison, Benoit Garin, Soanandrasana Rahelinirina, Fehivola Andriamiaramanana, Pascale Bourhy |
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| Přispěvatelé: | Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Biologie des Spirochètes / Biology of Spirochetes, Institut Pasteur [Paris], CHU Pointe-à-Pitre/Abymes [Guadeloupe], We would like to thank the staff of the Plague Unit, Institut Pasteur Madagascar for field and technical assistance, and the team of the Centre National de Référence de la Leptospirose, Institut Pasteur, Paris for technical assistance genotyping isolates. We thank D. Wagner for improving the English writing in the manuscript., Institut Pasteur [Paris] (IP) |
| Rok vydání: | 2019 |
| Předmět: |
MESH: Leptospira interrogans
Veterinary medicine [SDV]Life Sciences [q-bio] animal diseases 030231 tropical medicine MESH: Rodentia MESH: Leptospira law.invention MESH: Madagascar 03 medical and health sciences 0302 clinical medicine law Leptospira Virology MESH: Cities medicine MESH: Animals 030212 general & internal medicine MESH: Prevalence Polymerase chain reaction High prevalence Bacterial disease biology MESH: Kidney MESH: Leptospirosis bacterial infections and mycoses biology.organism_classification medicine.disease MESH: DNA Bacterial Leptospirosis 3. Good health Leptospira borgpetersenii Infectious Diseases Capital city bacteria Parasitology MESH: Rodent Diseases Leptospira interrogans |
| Zdroj: | American Journal of Tropical Medicine and Hygiene American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2019, 100 (5), pp.1079-1081. ⟨10.4269/ajtmh.18-0642⟩ American Journal of Tropical Medicine and Hygiene, 2019, 100 (5), pp.1079-1081. ⟨10.4269/ajtmh.18-0642⟩ |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.18-0642 |
| Popis: | International audience; Leptospirosis is a neglected zoonotic bacterial disease caused by pathogenic Leptospira spp. Only limited studies have been conducted on the presence of Leptospira spp. in rats in Antananarivo, the capital city of Madagascar. We assessed Leptospira prevalence in small mammals in urban areas of Antananarivo where sanitation is inadequate and there is risk of flooding during the rainy season. We captured rodents and shrews at two sites and examined kidney samples from 114 animals using culture and a real-time polymerase chain reaction (PCR) assay specific to pathogenic Leptospira spp. We identified 23 positive samples containing Leptospira interrogans and Leptospira borgpetersenii, with a high prevalence in Rattus norvegicus (44.9%). Our results indicate that small mammals, in particular R. norvegicus, present a major public health risk for acquiring leptospirosis in Antananarivo. |
| Databáze: | OpenAIRE |
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