Acetylcholine addition and electrical stimulation of dissociated neurons from an extended subthalamic area - A pilot study in the rat
| Autor: | Heida, Tjitske, Usunoff, K.G., Marani, Enrico, Jarm, T., Kramar, P., Zupanic, A. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
STN
Deep brain stimulation High frequency stimulation Chemistry medicine.medical_treatment Stimulation acetylcholine nervous system diseases Subthalamic nucleus METIS-241750 surgical procedures operative nervous system Electrical stimulation medicine BSS-Neurotechnology and cellular engineering EWI-10407 IR-61780 Neuroscience therapeutics Acetylcholine Low frequency stimulation medicine.drug |
| Zdroj: | 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007: MEDICON 2007, 26-30 June 2007, Ljubljana, Slovenia, 521-524 STARTPAGE=521;ENDPAGE=524;TITLE=11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007 11th Mediterranean Conference on Medical and Biomedical Engineering and Computing 2007 ISBN: 9783540730439 |
| Popis: | Addition of acetylcholine to cultures of STN area's (5 steps of 10 uM with a step interval of 1000s) show a direct and longlasting reduction of STN activity. Low frequency stimulation (20 Hz, 500 block pulses) increases STN activity, while high frequency stimulation (80 Hz, 2000 block pulses) reduces STN activity, even after the stimulation period of 25 seconds. |
| Databáze: | OpenAIRE |
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