Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection

Autor: Aylin Del Moral-Morales, Ernesto Soto-Reyes, Jan Baumbach, Rodrigo González-Barrios, Erick I. Navarro-Delgado, Nicolas Alcaraz, Marisol Salgado-Albarrán
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
TRIM25
Middle East respiratory syndrome coronavirus
QH301-705.5
Molecular Networks (q-bio.MN)
viruses
Systems analysis
Computational biology
Biology
medicine.disease_cause
General Biochemistry
Genetics and Molecular Biology
Article
Epigenesis
Genetic
Transcriptome
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Humans
Quantitative Biology - Molecular Networks
Epigenetics
Biology (General)
EP300
skin and connective tissue diseases
Transcription factor
Gene
SARS-CoV-2
Applied Mathematics
Gene Expression Profiling
fungi
virus diseases
COVID-19
Regulatory networks
Computer Science Applications
respiratory tract diseases
Gene expression profiling
030104 developmental biology
Severe acute respiratory syndrome-related coronavirus
030220 oncology & carcinogenesis
Modeling and Simulation
FOS: Biological sciences
Middle East Respiratory Syndrome Coronavirus
Signal Transduction
Zdroj: NPJ Systems Biology and Applications
Salgado-Albarrán, M, Navarro-Delgado, E I, Del Moral-Morales, A, Alcaraz, N, Baumbach, J, González-Barrios, R & Soto-Reyes, E 2021, ' Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection ', npj Systems Biology and Applications, vol. 7, no. 1, 21 . https://doi.org/10.1038/s41540-021-00181-x
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-14 (2021)
Salgado-Albarrán, M, Navarro-Delgado, E I, Del Moral-Morales, A, Alcaraz, N, Baumbach, J, González-Barrios, R & Soto-Reyes, E 2021, ' Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection ', n p j Systems Biology and Applications, vol. 7, 21 . https://doi.org/10.1038/s41540-021-00181-x
ISSN: 2056-7189
DOI: 10.1038/s41540-021-00181-x
Popis: COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that have therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19.
Comment: 33 pages, 2 tables, 5 figures, 4 supplementary figures
Databáze: OpenAIRE
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