Molecular cloning of RI-HB, a heparin binding protein regulated by retinoic acid
| Autor: | Maryvonne Laurent, Delphine Duprez, Yves Courtois, Jean-Pierre Le Caer, Marc Vigny, Paul Urios |
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| Rok vydání: | 1991 |
| Předmět: |
Molecular Sequence Data
Restriction Mapping Biophysics Retinoic acid Gene Expression Tretinoin Chick Embryo Molecular cloning Biology Biochemistry Avian Proteins chemistry.chemical_compound Complementary DNA Animals RNA Messenger Northern blot Cloning Molecular Molecular Biology Messenger RNA Base Sequence Heparin Binding protein Intracellular Signaling Peptides and Proteins Nucleic acid sequence DNA Cell Biology Blotting Northern Molecular biology Retinoic acid receptor chemistry Carrier Proteins |
| Zdroj: | Biochemical and Biophysical Research Communications. 175:617-624 |
| ISSN: | 0006-291X |
| Popis: | RI-HB is an extracellular heparin binding protein regulated by retinoic acid and essentially expressed during embryogenesis. This study reports the cloning and sequencing of the cDNA that encodes RI-HB. The sequence of RI-HB contains 121 amino acid residues and is very rich in basic amino acids and cysteines. This sequence was compared to those of HBGAM and MK protein, two other heparin binding proteins exhibiting growth and/or neurotrophic activities. Northern blot analysis indicates that RI-HB mRNA is strongly expressed during early chicken embryogenesis and that it is induced by retinoic acid treatment of chicken fibroblasts and myotubes in culture. |
| Databáze: | OpenAIRE |
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