| Autor: |
Brancato, D., Biondi, B., Attardo, T. M., Fierro, A., Nizzoli, M., Vettor, R., Monaco, E., Romano, R., Ariete, V., Usai, C., Zagarrì, E., Campanini, M. |
| Přispěvatelé: |
Brancato, D, Biondi, B, Attardo, Tm, Fierro, A, Nizzoli, M, Vettor, R, Monaco, E, Romano, R, Ariete, V, Usai, C, Zagarrì, E, Campanini, M |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Endocrinology. 13 |
| ISSN: |
1664-2392 |
| Popis: |
Background and aimsThere is still limited knowledge regarding the clinical profile and appropriateness of treatment in patients with hypothyroidism hospitalized in Internal Medicine (IM) Departments in Italy. The aim of this study is to evaluate: 1) the characteristics of patients and possible deviations from national and international clinical practice recommendations (CPRs) in evidence-based guidelines (EBGs); 2) the improvement of patient management by means of a standardized educational programme (EP).MethodsA nationwide multicentre study, comprising two replications of a retrospective survey (phases 1 and 3) with an intervening EP (phase 2) in half of the centres and no EP in the other half, was conducted. The EP was based on outreach visits. Centres were assigned to the two arms of the study, labelled the training group (TG) and control group (CG) respectively, by cluster randomization. Four EBGs and 39 CPRs provided the basis on which 22 treatment management indicators were identified (7 referring to the time of hospital admission, 15 to post-admission).ResultsThe 21 participating centres recruited 587 hospitalized patients with hypothyroidism, 421 of which were females (71.7%, mean age 74.1 + 14.4 yrs): 318 in phase 1 and 269 in phase 3. The cause of hypothyroidism was unknown in 282 patients (48%). Evaluation at the time of admission identified satisfactory adherence to CPRs (>50%) for 63.6% of the indicators. In the phase 3, TG centres showed significant improvement vs CG in 4 of the 15 post-admission indicators, while 1 out of 15 was significantly worse.ConclusionsThe EP based on outreach visits significantly improved some indicators in the management of patients with hypothyroidism, with specific reference to appropriateness of TSH dosage and levothyroxine (LT4) treatment modality.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT05314790. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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