Hepcidin Expression in the Liver: Relatively Low Level in Patients with Chronic Hepatitis C
| Autor: | Shozo Watanabe, Ryosuke Sugimoto, Yoshinao Kobayashi, Yukihiko Adachi, Naoki Fujita, Hideaki Tanaka, Masahiko Kaito, Rumi Mifuji, Naohito Urawa, Motoh Iwasa, Masaki Takeo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty Alcoholic liver disease Iron Overload Iron Hepacivirus Gastroenterology Hemoglobins Hepcidins Hepcidin Internal medicine Nonalcoholic fatty liver disease Genetics medicine Humans Aspartate Aminotransferases RNA Messenger Molecular Biology Genetics (clinical) Aged Hepatitis biology medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Transferrin saturation business.industry Liver Diseases Transferrin Alanine Transaminase Articles Hepatitis C Hepatitis C Chronic Middle Aged Hepatitis B medicine.disease Liver Ferritins Immunology biology.protein Serum iron RNA Viral Molecular Medicine Female business Antimicrobial Cationic Peptides |
| Zdroj: | Molecular Medicine. 13:97-104 |
| ISSN: | 1528-3658 1076-1551 |
| Popis: | Patients with chronic hepatitis C frequently have serum and hepatic iron overload, but the mechanism is unknown. Recently identified hepcidin, exclusively synthesized in the liver, is thought to be a key regulator for iron homeostasis and is induced by infection and inflammation. This study was conducted to determine the hepatic hepcidin expression levels in patients with various liver diseases. We investigated hepcidin mRNA levels of liver samples by real-time detection-polymerase chain reaction; 56 were hepatitis C virus (HCV) positive, 34 were hepatitis B virus (HBV) positive, and 42 were negative for HCV and HBV (3 cases of auto-immune hepatitis, 7 alcoholic liver disease, 13 primary biliary cirrhosis, 9 nonalcoholic fatty liver disease, and 10 normal liver). We analyzed the relation of hepcidin to clinical, hematological, histological, and etiological findings. Hepcidin expression levels were strongly correlated with serum ferritin (P < 0.0001) and the degree of iron deposit in liver tissues (P < 0.0001). Hepcidin was also correlated with hematological parameters (vs. hemoglobin, P = 0.0073; vs. serum iron, P = 0.0012; vs. transferrin saturation, P < 0.0001) and transaminase levels (P = 0.0013). The hepcidin-to-ferritin ratio was significantly lower in HCV(+) patients than in HBV(+) patients (P = 0.0129) or control subjects (P = 0.0080). In conclusion, hepcidin expression levels in chronic liver diseases were strongly correlated with either the serum ferritin concentration or degree of iron deposits in the liver. When adjusted by either serum ferritin values or hepatic iron scores, hepcidin indices were significantly lower in HCV(+) patients than in HBV(+) patients, suggesting that hepcidin may play a pivotal role in the pathogenesis of iron overload in patients with chronic hepatitis C. |
| Databáze: | OpenAIRE |
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