Adding value to tumor staging in head and neck cancer: The role of metabolic parameters as prognostic factors
| Autor: | José Ramón García-Berrocal, Sandra Carbonell, Raquel Benlloch, Jesús Romero, S. Marcos, Jefferson Rijo-Cedeño, Jorge Mucientes, Ana Royuela |
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| Přispěvatelé: | UAM. Departamento de Cirugía |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty MTV TLG Medicina medicine.medical_treatment Standardized uptake value 030218 nuclear medicine & medical imaging head and neck 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Internal medicine Positron Emission Tomography Computed Tomography medicine Humans cancer Neoplasm Staging Retrospective Studies Proportional hazards model business.industry Hazard ratio Head and neck cancer Cancer medicine.disease Prognosis Head and neck squamous-cell carcinoma Confidence interval Tumor Burden Radiation therapy PET Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Positron-Emission Tomography Radiopharmaceuticals business |
| Zdroj: | Biblos-e Archivo. Repositorio Institucional de la UAM Universitat Autònoma de Barcelona |
| Popis: | Background: Validated biomarkers in head and neck squamous cell carcinoma (HNSCC) are scarce. Methods: We retrospectively analyzed 62 patients with HNSCC treated with radiotherapy +/− concurrent chemotherapy. Pretreatment metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured in a 18F-FDG positron emission tomography using a liver dependent standardized uptake value threshold. Cox regression analyses were performed to find associations with disease-free survival (DFS) and overall survival (OS). Results: High values of MTV (>37 ml) were independently associated with a worse DFS (hazard ratio [HR] = 3.45; 95% confidence interval [CI], 1.52–7.84) and OS (HR = 3.27; 95% CI, 1.41–7.57). Similar results were found for high values of TLG (>247 g) for DFS (HR = 3.32; 95% CI, 1.44–7.65) and OS (HR = 3.42; 95% CI, 1.45–8.07). Conclusions: MTV and TLG can be considered as independent prognostic factors for DFS and OS in patients with HNSCC. Considering how easily obtainable they are, they may be useful for predicting clinical outcomes in these patients |
| Databáze: | OpenAIRE |
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