The role of oxidant-antioxidant markers and resistin in metabolic syndrome elderly individuals
| Autor: | Ewa Wysocka, Edyta Fatyga, Karolina Wyszomirska, Sylwia Dzięgielewska-Gęsiak, Małgorzata Muc-Wierzgoń |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adipose tissue 030204 cardiovascular system & hematology medicine.disease_cause Antioxidants 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Resistin 030304 developmental biology Aged Metabolic Syndrome 0303 health sciences Multidisciplinary business.industry Superoxide Dismutase Oxidant antioxidant medicine.disease Oxidants Endocrinology Glucose Metabolic syndrome business Oxidative stress Biomarkers Hormone |
| Zdroj: | Science progress. 104(2) |
| ISSN: | 2047-7163 |
| Popis: | In elderly, hormones and oxidant-antioxidant interplay are suggested to mediate biochemical balance between adipose tissue to other tissues. Thus the study attempts to explore metabolic traits, plasma resistin, and oxidant-antioxidant markers in metabolic syndrome (MetS) in comparison to non-metabolic syndrome (non-MetS) elderly individuals. A total of 541 healthy elderly Caucasians, with no acute and/or chronic disorders were invited. After taking into account inclusion/exclusion criteria’s the MetS was defined as the presence of three out of five abnormal findings and allowed to divided groups into: non-metabolic syndrome, non-MetS ( n = 25, median age 69.0 years), and newly diagnosed MetS ( n = 29; median age 70.5 years) individuals. Glucose, plasma lipids, resistin (Res), thiobarbituric acid-reacting substances (TBARS), total antioxidant status (TAS), and Cu,Zn-superoxide dismutase (SOD-1) were measured. The MetS had higher resistin than non-MetS ( p 2 = 0.23; p 2 = 0.53; p = 0.0004) moreover in that group TAS correlated negatively with HDL-C (β = −0.71; R = 0.72; R 2 = 0.37; p = 0.01). While age correlated negatively with systolic blood pressure (β = −0.60; R = 0.62; R 2 = 0.14; p = 0.03) independently from other factors in the non-MetS group. Various metabolic factors contribute to maintain serum resistin and oxidant-antioxidant balance in the elderly people in the presence or absence of MetS. Resistin may serve as a predictor of MetS in the elderly, while strong antioxidant defense interactions in older individuals may indicate good health. |
| Databáze: | OpenAIRE |
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