Anti-aging effects on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan, from roots of Lilium davidii var. unicolor Cotton
| Autor: | Haoyue Liu, Hui Jin, Haiyan Cui, Heping Hui, Aiyi Xin, Bo Qin, Xiaoyan Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aging
Pharyngeal pumping 02 engineering and technology medicine.disease_cause Biochemistry Plant Roots Lipid peroxidation Superoxide dismutase Mannans 03 medical and health sciences chemistry.chemical_compound Structural Biology Lilium davidii medicine Animals Caenorhabditis elegans Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species biology General Medicine 021001 nanoscience & nanotechnology Malondialdehyde biology.organism_classification Molecular biology Oxidative Stress chemistry Catalase biology.protein Lilium 0210 nano-technology Reactive Oxygen Species Oxidative stress |
| Zdroj: | International journal of biological macromolecules. 155 |
| ISSN: | 1879-0003 |
| Popis: | The anti-aging activities on Caenorhabditis elegans of a polysaccharide, O-acetyl glucomannan (LPR), purified from roots of Lilium davidii var. unicolor Cotton, were assessed by observing the mean lifespan, reproduction, pharyngeal pumping and stress response on nematodes. Additionally, the fluorescence intensity of lipofuscin and the level of reactive oxygen species (ROS) were detected. Also the activities of superoxide dismutase (SOD), catalase (CAT) and contents of malondialdehyde (MDA) were determined by the kit method. The results showed that LPR effectively delayed the aging of C. elegans in a dose-dependent manner. When the concentration reached 4 mg/mL, LPR extended the mean lifespan of C. elegans by up to 40%, 61% (P |
| Databáze: | OpenAIRE |
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