Expression of Ki-67 in squamous cell carcinoma of the penis
| Autor: | Oliver W. Hakenberg, Manfred P. Wirth, Dag Dittert, Axel Meye, Navid Berdjis, Johannes B.W. Nippgen, Gustavo B. Baretton |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Urology medicine.medical_treatment Penile Neoplasm Penile Carcinoma Humans Medicine Penile cancer Penile Neoplasms Aged Retrospective Studies Aged 80 and over biology business.industry Middle Aged Prognosis medicine.disease Immunohistochemistry Ki-67 Antigen medicine.anatomical_structure Epidermoid carcinoma Ki-67 Carcinoma Squamous Cell biology.protein Lymphadenectomy business Penis |
| Zdroj: | BJU International. 96:146-148 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2005.05584.x |
| Popis: | OBJECTIVE To investigate the Ki-67 labelling index (LI) as a prognostic factor for the outcome of penile carcinoma, as in squamous cell carcinoma (SCC) of the larynx the expression of this marker correlates with histological features indicative of prognosis. PATIENTS AND METHODS We retrospectively analysed the records of 44 patients in whom primary SCC of the penis was treated with amputation and bilateral lymphadenectomy (pT1, in 24, pT2 in 20, pN+ in 10; G1 in 12, G2 in 28 and G3 in four). During a mean follow-up of 35.6 months, four patients had disease progression. Tumour tissue was stained immunohistochemically using the streptavidin-biotin method. The mean Ki-67 LI was defined as the percentage of total tumour cells that were Ki-67-positive. The results were compared with pathological tumour stage, grade, nodal status and clinical disease progression. RESULTS The mean (range) Ki-67 LI was 40.5 (6.4–93.0)%; a high mean Ki-67 LI was significantly inversely correlated with tumour differentiation (P |
| Databáze: | OpenAIRE |
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