Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures
| Autor: | Niranjana Natarajan, Lorie Hamiwka, Christopher W. Beatty, Juliane Gust |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Early discontinuation 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures 030225 pediatrics medicine Seizure control Humans Practice Patterns Physicians' Retrospective Studies business.industry Incidence (epidemiology) Infant Newborn Symptomatic seizures medicine.disease Discontinuation Phenobarbital Pediatrics Perinatology and Child Health Infectious etiology Anticonvulsants Female Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Child Neurology. 33:153-157 |
| ISSN: | 1708-8283 0883-0738 |
| Popis: | Neonatal seizures are treated with phenobarbital and prolonged treatment does not prevent postneonatal epilepsy. The authors documented factors influencing phenobarbital use and determined whether published data changed practice. A total of 83 neonates with symptomatic seizures, clinical or electrographic, were evaluated for treatment, incidence of postneonatal epilepsy, and associated factors. Median phenobarbital treatment was 81 days. Nineteen children (23%) developed postneonatal epilepsy. Longer duration of seizures and an infectious etiology were associated with postneonatal epilepsy suggesting no impact on duration of phenobarbital treatment. Treatment duration was associated with duration of seizures and use of a second antiseizure medication. This study supports early discontinuation of phenobarbital and suggests providers utilize factors such as use of a second antiseizure medication and time to seizure control to determine phenobarbital duration, despite prior studies suggesting no impact of treatment length. |
| Databáze: | OpenAIRE |
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