Small, Short-Duration, Dobutamine-Induced Perfusion Defects Are Not Associated With Adverse Prognosis in Intermediate-Risk Individuals Receiving Cardiovascular Magnetic Resonance Stress Imaging
| Autor: | Timothy M. Morgan, Sujethra Vasu, Brandon Stacey, Killian Robinson, Jason C. Haag, Dalane W. Kitzman, Craig A. Hamilton, William Gregory Hundley, Jennifer H. Jordan, Vinay Thohan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Vasodilator Agents Magnetic Resonance Imaging Cine Sensitivity and Specificity Article Stress imaging Text mining Risk Factors Dobutamine Internal medicine North Carolina Prevalence medicine Humans Radiology Nuclear Medicine and imaging Short duration Aged Aged 80 and over medicine.diagnostic_test business.industry Incidence Myocardial Perfusion Imaging Reproducibility of Results Magnetic resonance imaging Middle Aged Prognosis Survival Rate Cardiovascular Diseases Exercise Test Cardiology Female business Intermediate risk Perfusion Magnetic Resonance Angiography medicine.drug |
| Zdroj: | Journal of Computer Assisted Tomography. 38:427-433 |
| ISSN: | 0363-8715 |
| DOI: | 10.1097/rct.0000000000000046 |
| Popis: | The objective of this study was to assess the frequency and prognostic utility of small, short-duration left ventricular myocardial perfusion defects during dobutamine cardiovascular magnetic resonance (DCMR) stress imaging.We performed first-pass contrast-enhanced DCMR at peak stress in 331 consecutively recruited individuals (aged 68 ± 8 years, 50% men) at intermediate risk for a future cardiac event. Size, location, and persistence of low-signal intensity perfusion defects were recorded. Cardiac events were assessed by personnel blinded to imaging results for a median of 24 months after the DCMR.Among the 55 individuals (16.6%) who exhibited small (25% myocardial thickness) and short-duration (5 frames in persistence) perfusion defects, diabetes was more prevalent (P = 0.019) and no cardiac events were observed. Large, persistent perfusion defects were associated with coronary artery disease, prior myocardial infarction, and decreased left ventricular function (P0.001 for all) and increased 2-year risk for a cardiac event (hazard ratio, 10.3; P0.001; confidence interval, 3.3-33.0).In individuals with diabetes, hypertension, or coronary artery disease at intermediate risk for a future cardiac event, small, short-duration DCMR perfusion defects are not associated with increased 2-year risk for a subsequent cardiac event. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|