Phenolic-rich jaboticaba ( Plinia jaboticaba (Vell.) Berg) extracts prevent high-fat-sucrose diet-induced obesity in C57BL/6 mice
| Autor: | Márcio Hercules Caldas Moura, Maria Gabriela Bernardo da Cunha, Maria Inés Genovese, Marcela Roquim Alezandro |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male Time Factors Adipose Tissue White Myrtaceae Adipose tissue OBESIDADE Diet High-Fat Weight Gain Plinia 0404 agricultural biotechnology Insulin resistance Phenols Dietary Sucrose Hyperinsulinism Hyperinsulinemia medicine Animals Hypoglycemic Agents Insulin Tannin Obesity Food science Adiposity Dyslipidemias Hypolipidemic Agents chemistry.chemical_classification biology Plant Extracts 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040401 food science Mice Inbred C57BL Disease Models Animal Cholesterol chemistry Proanthocyanidin Hyperglycemia Anti-Obesity Agents Tannins Dyslipidemia Food Science |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2018.01.071 |
| Popis: | Obesity has been strongly associated to noncommunicable chronic diseases, and dietary phenolic compounds with reducing the risk of development of these diseases. Sabara jaboticaba (Plinia jaboticaba) is an Atlantic Forest native fruit, rich in phenolic compounds, such as ellagitannins proanthocyanidins and anthocyanins. We investigated whether phenolic-rich Sabara jaboticaba extracts (PRJE), with low (LT) or high (HT) tannin concentration can protect C57BL/6 mice from obesity, hyperglycemia, insulin resistance and dyslipidemia induced by high-fat-sucrose diet. Both PRJE, especially the HT extract, prevented the body weight gain while avoiding the white adipose tissues overgrowth. In addition, prevented high fasting blood glucose concentrations and attenuated the hyperinsulinemia. Furthermore, the HT extract prevented high total cholesterol levels. Taken together, our findings confirm that phenolic compounds from Sabara jaboticaba have antiobesity properties and that the tannins play a decisive role in these effects. |
| Databáze: | OpenAIRE |
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