Antiviral and Antitumor Effects of a Human Interferon Analog, IFN-αCon1, Assessed in Hamsters
| Autor: | Karen Duker, Lawrence Goldstein, Bruce W. Altrock, Katherine D. Fagin, Eleanor N. Fish, David Chang, No Well Stebbing, Helen R. Hockman |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Cyclophosphamide medicine.medical_treatment Immunology Hamster Alpha interferon Antineoplastic Agents Pharmacology Biology Vesicular stomatitis Indiana virus Virus Cell Line Interferon Cricetinae Virology Chlorocebus aethiops Enterovirus Infections medicine Animals Humans Encephalomyocarditis virus Interferon alfa Chemotherapy Mesocricetus Lymphoma Non-Hodgkin Interferon-alpha Fibroblasts biology.organism_classification Recombinant Proteins Kinetics Interferon Type I Cattle Female medicine.drug |
| Zdroj: | Journal of Interferon Research. 6:405-415 |
| ISSN: | 0197-8357 |
| DOI: | 10.1089/jir.1986.6.405 |
| Popis: | An analog of human alpha-and beta-interferons (IFN-alpha and -beta) (generally consisting of the most frequently observed amino acid residue at each position in the molecule) has pronounced antiviral and antiproliferative activity in human and hamster cells. Intraperitoneal administration of this analog (designated IFN-alpha Con 1) to hamsters at 10(6) to 10(8) U/kg resulted in proportional increases in plasma concentrations through 6 h of monitoring. IFN-alpha Con 1 at these doses effectively limited encephalomyocarditis virus (EMCV) infections of hamsters. A natural human IFN-alpha preparation was also active against virus infections in hamsters. The antitumor activity of IFN-alpha Con 1 and natural human IFN-alpha was assessed in hamsters inoculated with lethal TBD932 lymphosarcoma. Various IFN treatment schedules resulted in prolonged survival following tumor challenge. IFN-alpha Con 1 administered at 10(5) to 10(6) U/hamster daily for 9-12 days following tumor challenge was effective in delaying tumor development, as was a natural human IFN-alpha preparation. The efficacies of combined IFN and cyclophosphamide therapies were determined. Unlike the natural human subtype IFN-alpha A, IFN-alpha Con 1 did not diminish the efficacy of cyclophosphamide (2.5 mg/hamster for 3 days) against the lymphosarcoma. However, an ineffective dose of cyclophosphamide (0.05 mg/hamster for 3 days) when combined with IFN-alpha Con 1 treatment showed enhanced antitumor activity. Combinations of cimetidine (16 mg/hamster for 4 days) and IFN-alpha Con 1 treatment did not prolong survival in this model system. |
| Databáze: | OpenAIRE |
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