Dopexamine prevents depression of mesenteric blood flow caused by positive end-expiratory pressure in rats
| Autor: | Steven M. Steinberg, Lewis M. Flint, Ella Choe, George Azar, Robert D. H. Lee, Robert Love |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Mean arterial pressure Cardiac output medicine.medical_treatment Dopamine Vasodilator Agents Dopexamine Positive-Pressure Respiration Rats Sprague-Dawley medicine Animals Splanchnic Circulation Cardiac Output Positive end-expiratory pressure Mechanical ventilation Dose-Response Relationship Drug business.industry Blood flow respiratory system respiratory tract diseases Rats Dose–response relationship Blood pressure Anesthesia Surgery business therapeutics circulatory and respiratory physiology medicine.drug |
| Zdroj: | Surgery. 120(4) |
| ISSN: | 0039-6060 |
| Popis: | Background. The purpose of this study was to investigate the effects of two vasoactive agents, dopamine and dopexamine, on the depression of mesenteric blood flow caused by positive end-expiratory pressure (PEEP) during mechanical ventilation. Methods. Sprague-Dawley rats were mechanically ventilated with either no PEEP (control group) or increasing levels of PEEP (PEEP group) up to 20 cm H 2 O pressure. We evaluated PEEP's effect on blood pressure, cardiac output (CO), and the mesenteric microcirculation with a continuous infusion of 2.5 or 12.5 μg/kg/min dopamine or 1, 3, or 5 μg/kg/min dopexamine. Results. PEEP caused a 20% to 25% decrease in mean arterial pressure and a 30% decrease in CO at both 15 and 20 cm H 2 O of PEEP (all p < 0.05 versus baseline). Low dose dopamine partially corrected the decrease in CO to 16% and 21% below baseline at 15 and 20 cm H 2 O of PEEP, respectively (both p < 0.05 versus PEEP group) and partially ameliorated the depression of mesenteric blood flow associated with the application of PEEP. High dose dopamine did not positively affect either CO or mesenteric blood flow. Dopexamine had little effect on CO compared with dopamine. All three doses of dopexamine blocked the effect of PEEP on mesenteric blood flow (p < 0.05 compared with the PEEP group at all levels of PEEP, p < 0.05 compared with the low dose dopamine group at 15 and 20 cm H 2 O of PEEP). Conclusions. Dopexamine is superior to dopamine in protecting mesenteric blood flow in the face of increasing levels of PEEP. |
| Databáze: | OpenAIRE |
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