Frequency of HIV type 1 dual infection and HIV diversity: analysis of low- and high-risk populations in Mbeya Region, Tanzania
| Autor: | Martina Gerhardt, Oliver Hoffmann, Sucheep Piyasirisilp, Miguel A. Arroyo, Karl-Heinz Herbinger, Deborah L. Birx, Doreen Mloka, Leonard Maboko, Francine E. McCutchan, Michael Hoelscher, Donan Mmbando |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Adolescent Sexual Behavior Immunology Population Blood Donors HIV Infections Tanzania Acquired immunodeficiency syndrome (AIDS) HIV Seroprevalence Virology HIV Seropositivity medicine Humans Sida education Genotyping education.field_of_study Chi-Square Distribution biology Unsafe Sex Genetic Variation biology.organism_classification medicine.disease Infectious Diseases Lentivirus Cohort DNA Viral HIV-1 Female Viral disease Demography |
| Zdroj: | AIDS research and human retroviruses. 22(7) |
| ISSN: | 0889-2229 |
| Popis: | HIV-1 diversity, frequency of recombinants, and dual infection were determined in two populations with different HIV risk behavior. A high-risk cohort of 600 female bar workers and a normal-risk population of 1,108 antenatal clinic attendees and blood donors were recruited. Behavioral data were assessed and blood for HIV- 1 diagnosis and genotyping was sampled. HIV-1 subtypes were defined through the multiregion hybridization assay (MHA(acd)). HIV-1 prevalence differed significantly among the two populations. The prevalence was 67.8% in the population of bar workers and 17% in the normal-risk population (antenatal care attendees and blood donors). Within the normal-risk population the HIV-1 prevalence was lowest in the group of volunteer blood donors. The frequency of HIV-1 infection in women was 1.7 times higher than in men. The overall subtype distribution was A (8.5%), C (40.8%), D (3.8%), AC (25.4%), AD (5.4%), CD (8.8%), and ACD (7.3%). In the high-risk population there was a higher percentage of HIV-1 recombinant strains (54% vs. 40%, p0.05) and a higher frequency of dual infections (19% vs. 9%, p0.02) compared to the normal-risk population. High-risk populations may play an important role in the evolution of HIV, as they can provide an opportunity for the virus to coinfect, recombine, and adapt to the host-specific genetic background. |
| Databáze: | OpenAIRE |
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