Atypical Microglandular Hyperplasia of Endocervix as the Presenting Feature of Plasminogen Deficiency
| Autor: | Colin J.R. Stewart |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Stromal cell Biopsy Cervix Uteri Fibrin Pathology and Forensic Medicine Endometrium 03 medical and health sciences 0302 clinical medicine medicine Humans Endocervical Mucosa Past medical history medicine.diagnostic_test biology business.industry Skin Diseases Genetic Obstetrics and Gynecology Plasminogen Conjunctivitis Microglandular hyperplasia 030104 developmental biology 030220 oncology & carcinogenesis Endometrial Hyperplasia biology.protein Female business Endocervix Endometrial biopsy |
| Zdroj: | International Journal of Gynecological Pathology. 40:224-228 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/pgp.0000000000000694 |
| Popis: | A 30-yr-old patient with no significant past medical history presented with postcoital bleeding and was found to have fibrinous pseudomembranous lesions overlying and partly in continuity with the endocervical mucosa. Histologically, these were characterized by an atypical microglandular proliferation that was associated with extensive fibrinous exudate and a prominent neutrophil polymorph infiltrate. Ligneous stromal alteration was not identified but the changes prompted hematologic review which confirmed plasminogen deficiency. A subsequent endometrial biopsy also demonstrated degenerate glands within a fibrin-rich matrix. This is the third case demonstrating an association between atypical endocervical microglandular hyperplasia and plasminogen deficiency. The diagnosis should also be considered when biopsies demonstrate exuberant fibrin exudate even if ligneous disease is not present. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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