Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol: a sub-group analysis of the BISO-CAD study
| Autor: | Yun-Dai Chen, Xin-Chun Yang, Vinh Nguyen Pham, Shi-An Huang, Guo-Sheng Fu, Xiao-Ping Chen, Binh Quang Truong, Yu Yang, Shao-Wen Liu, Tian-Rong Ma, Dong-Soo Kim, Tae-hoon Kim, Ning-Ning Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Bisoprolol Fumarate
China medicine.medical_specialty Acute coronary syndrome lcsh:Medicine Cardiac outcome Coronary Artery Disease Coronary artery disease 03 medical and health sciences 0302 clinical medicine Heart Rate Risk Factors Internal medicine Republic of Korea medicine Bisoprolol Humans Aged Retrospective Studies business.industry lcsh:R Original Articles General Medicine Odds ratio Middle Aged Prognosis Resting heart rate medicine.disease Confidence interval Blood pressure 030220 oncology & carcinogenesis Heart failure Hypertension Cardiology business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 133, Iss 10, Pp 1155-1165 (2020) |
| ISSN: | 2542-5641 0366-6999 |
| Popis: | Background. Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension. Methods. We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study (n = 866), which was a phase IV, multination, multi-center, single-arm, observational study carried out from October 2011 to July 2015 across China, South Korea, and Vietnam. Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome (CCCO), the results were presented as adjusted odds ratio (OR) along with 95% confidence interval (CI) and adjusted P value. Results. A total of 681 patients (mean age: 64.77 ± 10.33 years) with hypertension from BISO-CAD study were included in the analysis. Bisoprolol improved CCCOs in CAD patients with comorbid hypertension, with RHR |
| Databáze: | OpenAIRE |
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