New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum
| Autor: | Raquel Jadulco, Gernot Brauers, Ru Angelie Edrada, Rainer Ebel, Victor Wray, null Sudarsono, Peter Proksch |
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| Rok vydání: | 2002 |
| Předmět: |
Staphylococcus aureus
Antifungal Agents Stereochemistry Pharmaceutical Science Anthraquinones Fungus Bacillus subtilis Spodoptera Analytical Chemistry Phthalide chemistry.chemical_compound Anti-Infective Agents Drug Discovery Candida albicans medicine Escherichia coli Mediterranean Sea Animals Nuclear Magnetic Resonance Biomolecular Pharmacology biology Molecular Structure Organic Chemistry Fungi Fungi imperfecti Feeding Behavior biology.organism_classification Anti-Bacterial Agents Porifera medicine.drug_formulation_ingredient Sponge Complementary and alternative medicine chemistry Callyspongia Indonesia Cladosporium herbarum Molecular Medicine Chromatography Thin Layer Artemia Abscisic Acid |
| Zdroj: | Journal of natural products. 65(5) |
| ISSN: | 0163-3864 |
| Popis: | The fungus Curvularia lunata, isolated from the marine sponge Niphates olemda, yielded the new 1,3,8-trihydroxy-6-methoxyanthraquinone, which we named lunatin (1), the known modified bisanthraquinone cytoskyrin A (2), and the known plant hormone (+)-abscisic acid (3). Both anthraquinones were found to be active against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Two strains of the fungus Cladosporium herbarum, isolated from the sponges Aplysina aerophoba and Callyspongia aerizusa, respectively, yielded two new alpha-pyrones, herbarin A (4) and herbarin B (5), the known compound citreoviridin A (6), and the new phthalide herbaric acid (7). All structures were unambiguously established by 1D and 2D NMR and MS data. |
| Databáze: | OpenAIRE |
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