Vaccine-Associated Neurological Adverse Events: A Case Report and Literature Review
| Autor: | Lei Li, Juan Li, Maoqiang Tian, Xiaomei Shu, Wenting Lei, Jing Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Population medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Risk Factors Febrile seizure Drug Discovery medicine Humans Paralysis 030212 general & internal medicine education Adverse effect Child Pharmacology Poliomyelitis vaccine education.field_of_study Guillain-Barre syndrome business.industry Poliovirus Vaccination medicine.disease Immunization Poliovirus Vaccine Oral business 030217 neurology & neurosurgery |
| Zdroj: | Current pharmaceutical design. 25(43) |
| ISSN: | 1873-4286 |
| Popis: | Vaccination is an effective strategy to reduce the burden of preventable illness. However, many clinical reports revealed that various vaccinations may associate with neurological disorders, mainly including autoimmune disease, febrile seizure, and vaccine-associated paralytic poliomyelitis (VAPP). Although more and more reports revealed that part of the above post-vaccine neurological disorders is not directly related to vaccination, it may be merely a coincidence. However, these reports may increase the hesitancy on vaccination for the public population and influence the coverage of vaccination. In this report, we described a child with acute flaccid paralysis possibly caused by a poliovirus vaccine. To provide feasible ways to realize or reduce the risk of neurological adverse events caused by vaccines, we further provide a mini-review of the literature of vaccination associated with neurological adverse events. This revealed that oral poliomyelitis vaccine use exclusively and type 2 serotype poliomyelitis vaccine virus were the risk factors for VAPP. The combination vaccine was associated with an increased risk of ADEM and FS following immunization when compared with the administration of vaccines separately. Even though cases have been reported that vaccination may be a trigger of anti-NMDARe and GBS, there is no direct evidence to prove that vaccination increased the risk of GBS and anti-NMDARe. |
| Databáze: | OpenAIRE |
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