Early use of canakinumab to prevent mechanical ventilation in select COVID-19 patients: A retrospective, observational analysis
| Autor: | Antonio Mastroianni, Sonia Greco, Luciana Chidichimo, Filippo Urso, Francesca Greco, Maria V Mauro, Valeria Vangeli |
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| Rok vydání: | 2021 |
| Předmět: |
Male
interleukin-1β Immunology Interleukin-1beta mechanical ventilation Antibodies Monoclonal Humanized canakinumab Time-to-Treatment Monitoring Immunologic Immunology and Allergy Humans Original Research Article Retrospective Studies Pharmacology Dose-Response Relationship Drug SARS-CoV-2 Patient Selection case series COVID-19 biomarkers Middle Aged Respiration Artificial Outcome and Process Assessment Health Care Italy Female Inflammation Mediators |
| Zdroj: | International Journal of Immunopathology and Pharmacology |
| ISSN: | 2058-7384 |
| Popis: | Introduction The fully-human monoclonal anti-interleukin (IL)-1β antibody canakinumab may inhibit the production of inflammatory mediators in patients with coronavirus disease 2019 (COVID-19) and the hyperinflammatory response potentially leading to acute respiratory distress syndrome. Objectives The goal of our retrospective, observational analysis was to evaluate the safety and efficacy of subcutaneous (s.c.) canakinumab in combination with our standard of care (SOC) treatment of selected patients with COVID-19 with respiratory failure and elevated reactive pro-inflammatory markers. Methods Eight participants received two doses of s.c. canakinumab 150 mg (or 2 mg/kg for participants weighing ≤40 kg) in addition to SOC. 12 patients received only SOC treatment. Results Canakinumab treatment reduced the need for mechanical ventilation and reduced proinflammatory markers, resulting in an amelioration of the final outcome, with respect to the control group who received SOC alone. The treatment was safe and well tolerated; no adverse events were reported. Conclusion The use of canakinumab (300 mg, s.c.) in the early stage of COVID-19 with mild-to-moderate respiratory failure was superior to SOC at preventing clinical deterioration and may warrant further investigation as a treatment option for patients with COVID-19 who experience a hyperinflammatory response in the early stage of the disease. |
| Databáze: | OpenAIRE |
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