Invasive aspergillosis due to Aspergillus cryptic species: A prospective multicentre study

Autor: Laurence Lachaud, Christine Schuttler, Damien Costa, Lilia Hasseine, Sophie Cassaing, Marion Blaize, Juliette Guitard, Frédéric Gabriel, Sébastien Imbert, Sophie Brun, Renaud Piarroux, Arnaud Fekkar, Anne-Cécile Normand, Marijke Hendrickx, Hélène Raberin, Christine Bonnal, Lise Kristensen
Přispěvatelé: Service de parasitologie - mycologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Bordeaux [Bordeaux], CHU Rouen, Normandie Université (NU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nice (CHU Nice), Aarhus University Hospital, Service de Parasitologie - Mycologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU Saint-Etienne, Hôpital Avicenne [AP-HP], Institut Scientifique de Santé Publique [Belgique] - Scientific Institute of Public Health [Belgium] (WIV-ISP), Réseau International des Instituts Pasteur (RIIP), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), CHU Saint-Antoine [AP-HP], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Rok vydání: 2021
Předmět:
Zdroj: Imbert, S, Cassaing, S, Bonnal, C, Normand, A C, Gabriel, F, Costa, D, Blaize, M, Lachaud, L, Hasseine, L, Kristensen, L, Guitard, J, Schuttler, C, Raberin, H, Brun, S, Hendrickx, M, Piarroux, R & Fekkar, A 2021, ' Invasive aspergillosis due to Aspergillus cryptic species : A prospective multicentre study ', Mycoses, vol. 64, no. 11, pp. 1346-1353 . https://doi.org/10.1111/myc.13348
Mycoses
Mycoses, Wiley, 2021, ⟨10.1111/myc.13348⟩
Mycoses, 2021, ⟨10.1111/myc.13348⟩
ISSN: 1439-0507
0933-7407
DOI: 10.1111/myc.13348
Popis: International audience; ObjectivesAspergillus cryptic species are increasingly recognised causes of Aspergillus diseases, including life-threatening invasive aspergillosis (IA). However, as their accurate identification remains challenging in a routine practice, few is known from a clinical and epidemiological perspective. Recently, the MSI application has emerged as a powerful tool for the detection and identification of Aspergillus cryptic species. We aimed to use to the network of users of the MSI application to conduct a multicentre prospective screening of Aspergillus cryptic species-related IA and analyse their epidemiological, clinical and mycological characteristics.MethodsOver a 27-month period, the clinical involvement of 369 Aspergillus cryptic isolates, from 13 French and Danish MSI application users, was prospectively analysed. Species identification was confirmed by DNA-sequencing and antifungal susceptibility testing was performed using EUCAST reference method. Fifty-one A fumigatus sensu stricto invasive cases were also analysed.ResultsFifteen cryptic isolates were responsible of IA. Eight species were involved, including 5 cases related to the species A sublatus. These species showed high rate of in vitro low susceptibility to antifungal drugs. In comparison with A fumigatus sensu stricto invasive cases, pre-exposure to azole drugs was significantly associated with cryptic IA (P = .02).DiscussionThis study brings new insights in cryptic species related IA and underlines the importance to identify accurately at the species level these Aspergillus isolates. The increasing use of antifungal drugs might lead in the future to an epidemiologic shift with an emergence of resistant isolates involved in IA.
Databáze: OpenAIRE
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