Protective effect of captopril against diazinon induced nephrotoxicity and neurotoxicity via inhibition of ROS-NO pathway
| Autor: | Ehsan Zamani, Milad Arab-Nozari, Fatemeh Shaki, Hamidreza Mohammadi, Milad Vahidirad |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Captopril Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment 010501 environmental sciences Pharmacology Kidney Nitric Oxide Toxicology medicine.disease_cause 01 natural sciences Nephrotoxicity Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound medicine Animals Rats Wistar 0105 earth and related environmental sciences chemistry.chemical_classification Reactive oxygen species Chemical Health and Safety Public Health Environmental and Occupational Health Neurotoxicity Brain General Medicine Glutathione medicine.disease Rats 030104 developmental biology chemistry Biochemistry Diazinon Neurotoxicity Syndromes Lipid Peroxidation Reactive Oxygen Species Oxidative stress medicine.drug |
| Zdroj: | Drug and Chemical Toxicology. 41:287-293 |
| ISSN: | 1525-6014 0148-0545 |
| Popis: | Diazinon (Dz) is a widely used insecticide. It can induce nephrotoxicity and neurotoxicity via oxidative stress. Captopril, an angiotensin-converting enzyme inhibitor, is known for its antioxidant properties. In this study, we used captopril for ameliorating of Dz-induced kidney and brain toxicity in rats. Animals were divided into five groups as follows: negative control (olive oil), Dz (150 mg kg−1), captopril (60 and 100 mg kg−1) and positive control (N-acetylcysteine 200 mg kg−1) were injected intraperitoneally 30 min before Dz. After 24 h, animals were anesthetized and the brain and kidney tissues were separated. Then oxidative stress factors were evaluated. Also, blood was collected for assessment of blood urea nitrogen (BUN), creatinine (Cr) and nitric oxide (NO) levels. Dz significantly increased oxidative stress markers such as reactive oxygen species (ROS), lipid peroxidation, and protein carbonyl as well as glutathione (GSH) oxidation in both tissues. Increased levels of the BUN, Cr and... |
| Databáze: | OpenAIRE |
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