The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms
| Autor: | Karl Hawkins, Lydia C. Powell, Rolf Myrvold, Ahmed Sowedan, Saira Khan, Edvar Onsoyen, Katja E. Hill, David Thomas, Chris J. Wright |
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| Rok vydání: | 2013 |
| Předmět: |
Acinetobacter baumannii
Alginates Oligosaccharides Microbial Sensitivity Tests Aquatic Science medicine.disease_cause Applied Microbiology and Biotechnology Bacterial Adhesion Microbiology Hydrodynamic shear Elastic Modulus medicine Water Science and Technology chemistry.chemical_classification biology Rheometry Atomic force microscopy Pseudomonas aeruginosa Chemistry Biofilm Oligosaccharide biology.organism_classification In vitro Biomechanical Phenomena Biofilms Hydrodynamics Stress Mechanical Laminaria Rheology Shear Strength |
| Zdroj: | Biofouling. 29(4) |
| ISSN: | 1029-2454 |
| Popis: | The influence of a novel, safe antibiofilm therapy on the mechanical properties of Pseudomonas aeruginosa and Acinetobacter baumannii biofilms in vitro was characterized. A multiscale approach employing atomic force microscopy (AFM) and rheometry was used to quantify the mechanical disruption of the biofilms by a therapeutic polymer based on a low-molecular weight alginate oligosaccharide (OligoG). AFM demonstrated structural alterations in the biofilms exposed to OligoG, with significantly lower Young’s moduli than the untreated biofilms, (149 MPa vs 242 MPa; p |
| Databáze: | OpenAIRE |
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