Pancreatic regulation of glucose homeostasis
| Autor: | Bingbing Wu, Pia V. Röder, Weiping Han, Yixian Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Cell Communication Review Biology Bioinformatics Biochemistry Glucagon Islets of Langerhans 03 medical and health sciences Internal medicine Diabetes mellitus medicine Animals Homeostasis Humans Insulin Glucose homeostasis Pancreas Molecular Biology Type 2 Diabetes Mellitus medicine.disease Pancreas Exocrine Glucose 030104 developmental biology Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 Molecular Medicine Signal Transduction Hormone |
| Zdroj: | Experimental & Molecular Medicine |
| ISSN: | 2092-6413 |
| DOI: | 10.1038/emm.2016.6 |
| Popis: | In order to ensure normal body function, the human body is dependent on a tight control of its blood glucose levels. This is accomplished by a highly sophisticated network of various hormones and neuropeptides released mainly from the brain, pancreas, liver, intestine as well as adipose and muscle tissue. Within this network, the pancreas represents a key player by secreting the blood sugar-lowering hormone insulin and its opponent glucagon. However, disturbances in the interplay of the hormones and peptides involved may lead to metabolic disorders such as type 2 diabetes mellitus (T2DM) whose prevalence, comorbidities and medical costs take on a dramatic scale. Therefore, it is of utmost importance to uncover and understand the mechanisms underlying the various interactions to improve existing anti-diabetic therapies and drugs on the one hand and to develop new therapeutic approaches on the other. This review summarizes the interplay of the pancreas with various other organs and tissues that maintain glucose homeostasis. Furthermore, anti-diabetic drugs and their impact on signaling pathways underlying the network will be discussed. |
| Databáze: | OpenAIRE |
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