Histopathological and immunophenotypical assessment of canine primary splenic lymphoma according to the World Health Organization
| Autor: | Julielton S. Barata, Maiara B. Pucci, I.L.S. Senhorello, Felipe Augusto Ruiz Sueiro, Cristiano P. Fracácio, Paulo César Jark, Letícia Abrahão Anai |
|---|---|
| Přispěvatelé: | Parque Universitário, Laboratório VETPAT, Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pathology 040301 veterinary sciences CD3 Histopathology canine immunophenotypical Spleen caninos 0403 veterinary science linfoma esplênico 03 medical and health sciences linfoma indolente 0302 clinical medicine immune system diseases hemic and lymphatic diseases Medicine hematopoietic neoplasm patologia lcsh:Veterinary medicine splenic lymphoma General Veterinary biology business.industry 04 agricultural and veterinary sciences medicine.disease Marginal zone Lymphoma Histopatologia baço imunofenotípica medicine.anatomical_structure neoplasia hematopoiética 030220 oncology & carcinogenesis biology.protein lcsh:SF600-1100 indolent lymphoma Immunohistochemistry spleen pathology Antibody business Splenic Lymphoma |
| Zdroj: | Pesquisa Veterinária Brasileira v.38 n.11 2018 Pesquisa Veterinária Brasileira Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Pesquisa Veterinária Brasileira, Vol 38, Iss 11, Pp 2129-2132 |
| ISSN: | 1678-5150 0100-736X |
| DOI: | 10.1590/1678-5150-pvb-5328 |
| Popis: | Made available in DSpace on 2019-10-06T15:27:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-11-01. Added 1 bitstream(s) on 2019-10-09T18:34:49Z : No. of bitstreams: 1 S0100-736X2018001102129.pdf: 2127627 bytes, checksum: f29154f3653626354fa90c83069e9434 (MD5) Although there are several studies addressing multicentric lymphoma in dogs, data regarding splenic lymphoma remains scarce. The diagnosis of splenic lymphoma using the World Health Organization (WHO) classification system can aid prognostic characterization of splenic lymphoma. The aim of this study was to evaluate the most common histological types of splenic lymphoma in dogs from Brazil according to the WHO classification. We assessed 33 cases of splenic lymphoma diagnosed by histopathologic and immunohistochemical (IHC) analysis submitted to VETPAT- Pathology Laboratory, Campinas-SP, Brazil. IHC was performed using antibodies against CD3 for T-cell and CD79α for B-cell identification . Mean age of patients with splenic lymphoma was 9.8 years. The most affected breeds were mixed breed dogs (33%) followed by Pit bulls and Yorkshires (9.0%). The most prevalent histological type was marginal zone B-cell lymphoma (60.7%) followed by diffuse large B-cell lymphoma (12.1%) and lymphoblastic T-cell lymphoma (12.1%). Histological and immunohistochemical characterization of splenic lymphoma is important due to the high prevalence of indolent lymphomas such as marginal zone, which may be less aggressive and thus have different prognostic and distinct forms of treatment when compared to high-grade lymphomas. Departamento de Clínica Veterinária e Cirurgia Parque Universitário, Av. Hilário da Silva Passos 950 Laboratório VETPAT, Cel. Manuel de Morais 146 Departamento de Clínica Veterinária e Cirurgia Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista (Unesp), Via de acesso Prof. Dr. Paulo Donato Castellane s/n Departamento de Clínica Veterinária e Cirurgia Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista (Unesp), Via de acesso Prof. Dr. Paulo Donato Castellane s/n |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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