Evidence for respiratory viruses interactions in asymptomatic preschool-aged children
| Autor: | Christine Kottaridi, Vasiliki Matziou, Evangelos Bozas, Barbara Boutopoulou, Vasiliki Papaevangelou, K.N. Priftis, Konstantinos Douros, Apostolos Giotas, Doxa Kotzia |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Rhinovirus Adenoviridae Infections viruses Interactions Immunology Common Cold Respiratory Syncytial Virus Infections medicine.disease_cause Asymptomatic Article Virus Adenoviridae 03 medical and health sciences 0302 clinical medicine Influenza Human Humans Immunology and Allergy Medicine Prospective Studies Respiratory system Respiratory Tract Infections Children Respiratory viruses Greece business.industry General Medicine Orthomyxoviridae Prognosis Pathophysiology Respiratory Syncytial Viruses medicine.anatomical_structure 030228 respiratory system Child Preschool Asymptomatic Diseases Female medicine.symptom business 030215 immunology Respiratory tract |
| Zdroj: | Allergologia et Immunopathologia |
| ISSN: | 0301-0546 |
| Popis: | Aim To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children. Methods Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR DNA/RNA microarray system for nine respiratory viruses. Results Respiratory syncytial virus (RSV) was a predictor of the presence of influenza virus (INFL) (OR: 9.12, CI: 1.52–54.75, p = 0.016), and similarly, INFL predicted the presence of RSV (OR: 4.01, CI: 1.14–14.16, p = 0.030). Also, rhinovirus (RV) was a predictor of adenovirus (ADV) presence (OR: 3.66, CI: 1.10–12.14, p = 0.034), and similarly, ADV predicted the presence of RV (OR: 4.05, CI: 1.02–16.05, p = 0.046). No other significant associations between viruses were observed. Conclusion Our results indicate that respiratory viruses found in carrier stage in asymptomatic children may interact with other viruses and even facilitate their settling in the upper respiratory tract. The pathophysiological role of these interactions is not yet clear. |
| Databáze: | OpenAIRE |
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