Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance
| Autor: | Mao-Wei Ni, Zhi-Guo Zheng, Sheng-Jie Zhang, Xu Qiang, Jian-Guo Feng, Jie Zhou, Yun Zhou, Guo-Ming Zhou, Ying-Li Zhang, Han-Zhou Mou |
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| Rok vydání: | 2019 |
| Předmět: |
endocrine system diseases
Clinical Biochemistry Down-Regulation 030204 cardiovascular system & hematology Relapse free survival Cancer recurrence 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Platinum resistance Drug Discovery Serous ovarian cancer Medicine Humans Platinum Ovarian Neoplasms business.industry Biochemistry (medical) Middle Aged female genital diseases and pregnancy complications Drug Resistance Neoplasm 030220 oncology & carcinogenesis Potential biomarkers Cancer research Female RNA Long Noncoding Neoplasm Grading business |
| Zdroj: | Biomarkers in medicine. 13(7) |
| ISSN: | 1752-0371 |
| Popis: | Aim: To investigate the expression of long intergenic noncoding RNA 00515 (LINC00515) in high-grade serous ovarian cancer (HGSOC) and its potential correlation with platinum resistance. Patients & methods: Expression of LINC00515 in HGSOC (n = 115) and normal (n = 19) tissues was detected via quantitative real-time PCR (qRT-PCR). We further explored the statistical significance of the relationship between LINC00515 expression and platinum resistance in HGSOC. Results: LINC00515 was gradually downregulated in the order of normal > platinum-sensitive > platinum-resistant tissue (p < 0.05). Results demonstrated that LINC00515 downregulation was correlated with platinum resistance and relapse-free survival (RFS) of HGSOC (p < 0.05). Conclusion: LINC00515 downregulation is correlated with HGSOC development, platinum resistance and RFS, supporting its utility as a potential biomarker to predict platinum resistance and prognosis of RFS. |
| Databáze: | OpenAIRE |
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