Herb Sanqi-Derived Compound K Alleviates Oxidative Stress in Cultured Human Melanocytes and Improves Oxidative-Stress-Related Leukoderma in Guinea Pigs
| Autor: | Shaoqiong Xie, Yasutaka Kuroda, Huimin Zhang, Suwei Tang, Ichiro Katayama, Lingli Yang, Sylvia Lai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
Sanqi Ginsenosides QH301-705.5 Leukoderma Butanols Glutathione reductase Guinea Pigs Melanocyte Pharmacology medicine.disease_cause Neuroprotection Article chemistry.chemical_compound medicine Animals Humans oxidative stress leukoderma Biology (General) Hydrogen peroxide Cells Cultured Hypopigmentation Melanins Cell Death Chemistry General Medicine Glutathione Hydrogen Peroxide medicine.disease melanocytes medicine.anatomical_structure Glutathione Reductase Oxidation-Reduction Oxidative stress Drugs Chinese Herbal |
| Zdroj: | Cells, Vol 10, Iss 2057, p 2057 (2021) Cells Volume 10 Issue 8 |
| ISSN: | 2073-4409 |
| Popis: | Sanqi, a traditional Chinese herb, is widely used for cardiovascular diseases, and its neuroprotective effects against oxidative stress were recently discovered. The purpose of this study was to investigate whether Sanqi-derived compound K (Sanqi-CK), an active metabolite of Sanqi, could protect melanocytes from oxidative stress. Cultured human primary skin epidermal melanocytes (HEMn-MPs) were treated with hydrogen peroxide (H2O2) in the presence or absence of Sanqi-CK. Sanqi-CK exhibited protective effects against H2O2-induced cell death by reducing oxidative stress. In addition, treatment with Sanqi-CK reversed the decreased glutathione reductase activity and decreased ratio of reduced glutathione (GSH)/oxidized glutathione (GSSG) seen in H2O2-treated melanocytes. Furthermore, topical application of Sanqi-CK alleviated leukoderma in guinea pigs, a disorder characterized by melanocyte cell death resulting from rhododendrol-induced oxidative stress. Taken together, these data suggest that Sanqi-CK protects melanocytes against oxidative stress, and its protective effects are associated with modulating the redox balance between GSH and GSSG and activating glutathione reductase. Thus, Sanqi-CK may be a good candidate for preventing melanocyte loss in oxidative-stress-associated pigmentary disorders. |
| Databáze: | OpenAIRE |
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