Genetic Variations in Polyunsaturated Fatty Acid Metabolism Implications for Child Health?
| Autor: | Hans Demmelmair, Berthold Koletzko, Eva Lattka, Mario Klingler, Joachim Heinrich, Norman Klopp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Fatty Acid Desaturases
030309 nutrition & dietetics FADS1 FADS2 Medicine (miscellaneous) Single-nucleotide polymorphism Health Promotion Bioinformatics 03 medical and health sciences Child Development Nutrigenomics Genetic variation Humans Genetic Predisposition to Disease Precision Medicine Child 030304 developmental biology Genetic association chemistry.chemical_classification Genetics 0303 health sciences Polymorphism Genetic Nutrition and Dietetics biology Fatty acid Dietary Fats Asthma 3. Good health Fatty acid desaturase chemistry Fatty Acids Unsaturated biology.protein Cognition Disorders Polyunsaturated fatty acid |
| Zdroj: | Annals of Nutrition and Metabolism |
| ISSN: | 1421-9697 0250-6807 |
| DOI: | 10.1159/000337308 |
| Popis: | Sufficient nutritional supply with polyunsaturated fatty acids (PUFAs) has long been considered as beneficial for child health, especially in regard to neuronal development and allergic diseases. In recent years, genetic association studies showed that in addition to nutritional influences, the genetic background is highly important for PUFA composition in human tissues. Specifically, polymorphisms in the fatty acid desaturase genes or FADS determine the efficiency of how PUFAs are processed endogenously. Recent gene-nutrition interaction studies suggest that these polymorphisms modulate the effect of nutritional fatty acid intake on complex phenotypes such as cognitive outcomes and asthma risk in children. These early results may provide the basis for future well-specified dietary recommendations to achieve optimal health benefit for all children. This article presents results from recent gene-nutrition interaction studies, discusses its implications for child health, and gives an outlook how this association might translate into clinical practice in the future. |
| Databáze: | OpenAIRE |
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