Effects of dexmedetomidine on TNF-α and interleukin-2 in serum of rats with severe craniocerebral injury
| Autor: | Pai Peng, Qing-Hui Wang, Wan-Wei Jiang, Li-Xin Yin, Ya-Jing Liao, Min Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Agonist Male medicine.medical_specialty Adrenergic receptor medicine.drug_class Il-2 Femoral vein Severity of Illness Index lcsh:RD78.3-87.3 Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Anesthesiology Sedative/hypnotic medicine Adrenergic alpha-2 Receptor Agonists Animals Craniocerebral Trauma Dexmedetomidine business.industry Tumor Necrosis Factor-alpha Perioperative Rats Severe craniocerebral injury 030104 developmental biology Anesthesiology and Pain Medicine lcsh:Anesthesiology Anesthesia TNF-α Interleukin-2 Tumor necrosis factor alpha business 030217 neurology & neurosurgery Biomarkers medicine.drug Research Article |
| Zdroj: | BMC Anesthesiology BMC Anesthesiology, Vol 17, Iss 1, Pp 1-5 (2017) |
| ISSN: | 1471-2253 |
| Popis: | Background Dexmedetomidine is a highly selective adrenergic receptor agonist, which has a dose-dependent sedative hypnotic effect. Furthermore, it also has pharmacological properties, and the ability to inhibit sympathetic activity and improve cardiovascular stability during an operation. However, its protective effect on patients with severe craniocerebral injury in the perioperative period remains unclear. Method Eighty adult male SD rats were used and divided into two groups (n = 40, each group): dexmedetomidine injury group (experimental group), and sodium chloride injury group (control group). Models of severe craniocerebral injury were established in these two groups using the modified Feeney’s free-fall method. As soon as the establishment of models was succeed, rat in the experimental group received 1 μg of dexmedetomidine (0.1 ml), while each rat in the control group was given 0.1 ml of 0.9% sodium chloride. Blood was sampled from an incision at the femoral vein to detect TNF-α and IL-2 levels at 1, 12, 24,36,48 and 72 h after establishing the model in the two groups. Results After severe craniocerebral injury, TNF-α levels of rats were lower in every stage and at different degrees in the experimental group than in the control group (P |
| Databáze: | OpenAIRE |
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