Auditory DUM neurons in a bush-cricket: inhibited inhibitors

Autor: Andreas Stumpner, Silvia Gubert, Debbra Y. Knorr, Martin C. Göpfert
Rok vydání: 2020
Předmět:
Male
Auditory Pathways
Neurite
Physiology
Population
Biology
Inhibitory postsynaptic potential
GABA Antagonists
Gryllidae
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Hearing
Postsynaptic potential
medicine
Animals
Picrotoxin
Graded potential
education
gamma-Aminobutyric Acid
Ecology
Evolution
Behavior and Systematics
Inhibition
030304 developmental biology
Neurons
Original Paper
0303 health sciences
education.field_of_study
Excitatory Postsynaptic Potentials
Segmental interneurone
Immunohistochemistry
Ganglia
Invertebrate
medicine.anatomical_structure
Acoustic Stimulation
Inhibitory Postsynaptic Potentials
nervous system
chemistry
Auditory Perception
Excitatory postsynaptic potential
Female
Animal Science and Zoology
Soma
Insect
Neuroscience
030217 neurology & neurosurgery
Zdroj: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
ISSN: 1432-1351
0340-7594
Popis: Thoracic ganglia of many hearing insects house the first level of auditory processing. In bush-crickets, the largest population of local auditory neurons in the prothoracic processing centre are dorsal unpaired median (DUM) neurons. It has been suggested that DUM neurons are inhibitory using γ-aminobutyric acid (GABA) as transmitter. Immunohistochemistry reveals a population of about 35–50 GABA-positive somata in the posterior medial cluster of the prothoracic ganglion. Only very few small somata in this cluster remain unstained. At least 10 neurites from 10 neurons can be identified. Intracellularly stained auditory DUM neurons have their soma in the cluster of median GABA positive cells and most of them exhibit GABA-immunoreactivity. Responses of certain DUM neurons show obvious signs of inhibition. Application of picrotoxin (PTX), a chloride-channel blocker in insects, changes the responses of many DUM neurons. They become broader in frequency tuning and broader or narrower in temporal pattern tuning. Furthermore, inhibitory postsynaptic potentials (IPSPs) may be replaced by excitatory postsynaptic potentials. Loss of an IPSP in the rising graded potential after PTX-application leads to a significant reduction of first-spike latency. Therefore, auditory DUM neurons receive effective inhibition and are the best candidates for inhibition in DUM neurons and other auditory interneurons. Electronic supplementary material The online version of this article (10.1007/s00359-020-01438-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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