Didemnin B : comparative study and conpormational approach in solution

Autor:	Bernard Banaigs, Martin Wahl, Patrick Jouin, F. Lafargue, C. Francisco, Gerard Jeanty, Annie Heitz, J. C. Prome, Adrien Cavé, Joël Poncet
Rok vydání:	1989
Předmět:	Depsipeptide Residue (complex analysis) 010405 organic chemistry Stereochemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Didemnin B 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Statine
Zdroj:	Tetrahedron, 45 (1). pp. 181-190.
ISSN:	0040-4020
DOI:	10.1016/0040-4020(89)80045-6
Popis:	A comparative study of isodideimnine-1 and didemnin B is presented using spcctroecopic methods, partial degradation and partial synthesis. This leads to the conclusion of the presence of a single depsipeptide, namely didemnin B, with (3S,4R,5S) isostatine instead of the previous statine residue. An attempt to determine the whole conformation in solution of didemnin B by using 2D-NMR is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac135e324c5469ee040d62a60b1b21a https://doi.org/10.1016/0040-4020(89)80045-6 Zobrazit plný text záznamu