Experimental models and examination methods of retinal detachment
| Autor: | Zi-Yuan Zhang, Ying-Jian Sun, Bin Fan, Guang-Yu Li, Jing-Yao Song |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry General Neuroscience Retinal Detachment Retinal detachment Retinal Exudative retinal detachment medicine.disease Retina In vitro model 03 medical and health sciences chemistry.chemical_compound Disease Models Animal 030104 developmental biology 0302 clinical medicine chemistry Ophthalmology Genetic model Medicine Animals business 030217 neurology & neurosurgery |
| Zdroj: | Brain research bulletin. 169 |
| ISSN: | 1873-2747 |
| Popis: | Retinal detachment refers to the separation of the retinal neuroepithelium and pigment epithelium, usually involving the death of photoreceptor cells. Severe detachment may lead to permanent visual impairment if not treated properly and promptly. According to the underlying causes, retinal detachment falls into one of three categories: exudative retinal detachment, traction detachment, and rhegmatogenous retinal detachment. Like many other diseases, it is difficult to study the pathophysiology of retinal detachment directly in humans, because the human retinal tissues are precious, scarce and non-regenerative; thus, establishing experimental models that better mimic the disease is necessary. In this review, we summarize the existing models of the three categories of retinal detachment both in vivo and in vitro, along with an overview of their examination methods and the major strengths and weaknesses of each model. |
| Databáze: | OpenAIRE |
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