Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital Discharge

Autor:	Jaime Signes-Costa, Carolina Lahosa, Ada Luz Andreu, Ines Moret-Tatay, Jose Antonio Ros, Juan Luis Rodríguez-Hermosa, Juan Antonio Carbonell-Asins, Virginia Molina, José N. Sancho-Chust, Enrique Rodriguez-Borja, Alba Mulet, Amaia Lope-Martinez, Joan B. Soriano, Luis Cabanes, Cecilia López-Ramírez, Susana Herrera, Estrella Fernández-Fabrellas, Belen Safont, Julia Tarraso
Rok vydání:	2022
Předmět:	BMI body mass index DLCO diffusing capacity for carbon monoxide RT-PCR reverse transcriptase-polymerase chain reaction Pulmonary function testing mMRC modified British Medical Research Council Cambios fibróticos Pulmonary fibrosis Respiratory system skin and connective tissue diseases COVID-19 coronavirus disease 2019 Biomarcadores séricos Interstitial lung disease Secuelas por COVID-19 TC torácica VEGF vascular endothelial growth factor CT computed tomography Cohort MMP matrix metalloproteinases Original Article Cohort study Pulmonary and Respiratory Medicine medicine.medical_specialty COVID-19 sequelae Lung diffusion SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 6-MWT 6 minute-walk test ARDS acute respiratory distress syndrome BMI body mass index COPD chronic obstructive pulmonary disease COVID-19 sequelae COVID-19 coronavirus disease 2019 CT computed tomography Chest CT DLCO diffusing capacity for carbon monoxide Fibrotic changes GGO ground-glass opacity HFNC high flow nasal cannula oxygen ILD interstitial lung disease IMV mechanical ventilation Interstitial lung disease Lung diffusion MMP matrix metalloproteinases NIV non-invasive ventilation RALE radiographic assessment of lung edema RT-PCR reverse transcriptase-polymerase chain reaction SARS severe acute respiratory syndrome SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Serum biomarkers VEGF vascular endothelial growth factor mMRC modified British Medical Research Council sEGFR soluble epidermal growth factor receptor Chest CT Internal medicine medicine Difusión pulmonar SARS severe acute respiratory syndrome ARDS acute respiratory distress syndrome ComputingMethodologies_COMPUTERGRAPHICS IMV mechanical ventilation HFNC high flow nasal cannula oxygen RALE radiographic assessment of lung edema business.industry NIV non-invasive ventilation Serum biomarkers medicine.disease Enfermedad pulmonar intersticial respiratory tract diseases Pneumonia GGO ground-glass opacity COPD chronic obstructive pulmonary disease Pulmonary diffusion Fibrotic changes ILD interstitial lung disease 6-MWT 6 minute-walk test business sEGFR soluble epidermal growth factor receptor
Zdroj:	Archivos De Bronconeumologia ARCHIVOS DE BRONCONEUMOLOGIA r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname
ISSN:	0300-2896
DOI:	10.1016/j.arbres.2021.08.014
Popis:	Graphical abstract Introduction Impairment in pulmonary function tests and radiological abnormalities are a major concern in COVID-19 survivors. Our aim is to evaluate functional respiratory parameters, changes in chest CT, and correlation with peripheral blood biomarkers involved in lung fibrosis at two and six months after SARS-CoV-2 pneumonia. Methods COVID-FIBROTIC (clinicaltrials.gov NCT04409275) is a multicenter prospective observational cohort study aimed to evaluate discharged patients. Pulmonary function tests, circulating serum biomarkers, chest radiography and chest CT were performed at outpatient visits. Results In total, 313, aged 61.12 ± 12.26 years, out of 481 included patients were available. The proportion of patients with DLCO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabfe1843422093807a603ea0b50caa9 https://doi.org/10.1016/j.arbres.2021.08.014 Zobrazit plný text záznamu Full Text from ScienceDirect