Fresh fruit consumption may decrease the long‐term risk of esophageal cancer mortality: A 30‐year follow‐up study in the Linxian Dysplasia Nutrition Intervention trial (NIT)

Autor: Philip R. Taylor, You-Lin Qiao, Jianbing Wang, Huijiao Yan, Su Zhang, Jin-Hu Fan, Huan Yang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Esophageal Neoplasms
noncardia carcinoma
Population
Nutritional Status
Gastroenterology
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Risk Factors
Esophageal squamous cell carcinoma
Internal medicine
Carcinoma
medicine
Humans
education
Aged
Retrospective Studies
education.field_of_study
business.industry
Proportional hazards model
Hazard ratio
fresh fruit consumption
Original Articles
General Medicine
Middle Aged
Esophageal cancer
Prognosis
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Survival Rate
030104 developmental biology
Oncology
Dysplasia
Fruit
030220 oncology & carcinogenesis
Gastric Cardia Carcinoma
Cohort
gastric cardia carcinoma
Original Article
Female
Linxian dysplasia nutrition intervention trial
business
Follow-Up Studies
Zdroj: Thoracic Cancer, Vol 11, Iss 7, Pp 1918-1926 (2020)
Thoracic Cancer
ISSN: 1759-7706
1759-7714
Popis: Background The objective of this study was to explore the association between fresh fruit consumption and long-term risk of upper gastrointestinal cancer (UGI) in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort. Methods A cohort of 3318 subjects with esophageal squamous dysplasia participated in the Linxian Dysplasia NIT in May 1985 and were followed up until 30 September 2015. Demographic characteristics, lifestyle, and history of diseases were collected at the baseline. The primary endpoint was death from esophageal squamous cell carcinoma (ESCC), gastric cardia carcinoma (GCC), and gastric noncardia carcinoma (GNCC). Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model. Results In the 30-year follow-up, a total of 541 ESCC, 284 GCC, and 77 GNCC deaths occurred. Relative to those who never or rarely consumed fresh fruit, the risk of ESCC mortality in participants who consumed fresh fruit more than 12 times/year were significantly decreased by 37.3% (HR = 0.63, 95% CI: 0.49-0.81). In the subgroup analyses, significantly protective effects on ESCC mortality were observed especially in females (HR = 0.59, 95% CI: 0.40-0.89), non-smokers (HR = 0.67, 95% CI: 0.48-0.94), and nondrinkers (HR = 0.69, 95% CI: 0.51-0.93). Conclusions Consuming fresh fruit more than 12 times/year may reduce the long-term risk of ESCC mortality in this dysplasia population, particularly in females, non-smokers, and nondrinkers. Future studies are needed to confirm these findings.
Databáze: OpenAIRE
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