Fresh fruit consumption may decrease the long‐term risk of esophageal cancer mortality: A 30‐year follow‐up study in the Linxian Dysplasia Nutrition Intervention trial (NIT)
Autor: | Philip R. Taylor, You-Lin Qiao, Jianbing Wang, Huijiao Yan, Su Zhang, Jin-Hu Fan, Huan Yang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Esophageal Neoplasms noncardia carcinoma Population Nutritional Status Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Risk Factors Esophageal squamous cell carcinoma Internal medicine Carcinoma medicine Humans education Aged Retrospective Studies education.field_of_study business.industry Proportional hazards model Hazard ratio fresh fruit consumption Original Articles General Medicine Middle Aged Esophageal cancer Prognosis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Survival Rate 030104 developmental biology Oncology Dysplasia Fruit 030220 oncology & carcinogenesis Gastric Cardia Carcinoma Cohort gastric cardia carcinoma Original Article Female Linxian dysplasia nutrition intervention trial business Follow-Up Studies |
Zdroj: | Thoracic Cancer, Vol 11, Iss 7, Pp 1918-1926 (2020) Thoracic Cancer |
ISSN: | 1759-7706 1759-7714 |
Popis: | Background The objective of this study was to explore the association between fresh fruit consumption and long-term risk of upper gastrointestinal cancer (UGI) in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort. Methods A cohort of 3318 subjects with esophageal squamous dysplasia participated in the Linxian Dysplasia NIT in May 1985 and were followed up until 30 September 2015. Demographic characteristics, lifestyle, and history of diseases were collected at the baseline. The primary endpoint was death from esophageal squamous cell carcinoma (ESCC), gastric cardia carcinoma (GCC), and gastric noncardia carcinoma (GNCC). Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazard model. Results In the 30-year follow-up, a total of 541 ESCC, 284 GCC, and 77 GNCC deaths occurred. Relative to those who never or rarely consumed fresh fruit, the risk of ESCC mortality in participants who consumed fresh fruit more than 12 times/year were significantly decreased by 37.3% (HR = 0.63, 95% CI: 0.49-0.81). In the subgroup analyses, significantly protective effects on ESCC mortality were observed especially in females (HR = 0.59, 95% CI: 0.40-0.89), non-smokers (HR = 0.67, 95% CI: 0.48-0.94), and nondrinkers (HR = 0.69, 95% CI: 0.51-0.93). Conclusions Consuming fresh fruit more than 12 times/year may reduce the long-term risk of ESCC mortality in this dysplasia population, particularly in females, non-smokers, and nondrinkers. Future studies are needed to confirm these findings. |
Databáze: | OpenAIRE |
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