New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III

Autor:	Yun Fang Zhao, Xue Feng Huang, Wei Liu, Yin-Ru Wang, Susan L. Morris-Natschke, Kuo Hsiung Lee, Ting Ting Shang, Hong Yin, Yu Wei Zhang
Rok vydání:	2018
Předmět:	Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry Saponin Plant Science 01 natural sciences Biochemistry Analytical Chemistry Structure-Activity Relationship Anemarrhena asphodeloides Cell Line Tumor Humans Cytotoxic T cell chemistry.chemical_classification Anemarrhena Molecular Structure biology 010405 organic chemistry Hydrolysis Organic Chemistry Biological activity Saponins biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences 010404 medicinal & biomolecular chemistry Transformation (genetics) chemistry Steroids Acid hydrolysis Drug Screening Assays Antitumor
Zdroj:	Natural Product Research. 33:2755-2761
ISSN:	1478-6427 1478-6419
DOI:	10.1080/14786419.2018.1499640
Popis:	Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge. To potentially discover derivatives with better biological activity, timosaponin B III ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabb773627cbc43e551bc5d0d99b9d1c https://doi.org/10.1080/14786419.2018.1499640 Zobrazit plný text záznamu