Influence of Differential Calcification in the Descending Thoracic Aorta on Aortic Pulse Pressure
| Autor: | Steven C. Port, Mustafa Noor Muhammad, Suhail Allaqaband, Mirza Mujadil Ahmad, Anjan Gupta, Khawaja Afzal Ammar, Mirza Nubair Ahmad, Muhammad Nabeel Syed, Sharmeen Fatima Hussaini, Immad Arif Kiani, Imaad Razzaque, Syed Haris Ahmed Pir, Rafath Ullah |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Medicine 030204 cardiovascular system & hematology compliance calcification 03 medical and health sciences 0302 clinical medicine medicine.artery Internal medicine Ascending aorta medicine Thoracic aorta Aortic Pulse Pressure Original Research Aorta business.industry lcsh:R computed tomography pulse pressure General Medicine medicine.disease Pulse pressure 030104 developmental biology Descending aorta cardiovascular system Ventricular pressure Cardiology thoracic aortic business Calcification |
| Zdroj: | Journal of Patient-Centered Research and Reviews, Vol 4, Iss 3, Pp 104-113 (2017) |
| ISSN: | 2330-0698 |
| Popis: | Purpose: Multiple studies have shown pulse pressure (PP) to be a strong predictor of aortic calcification. However, no studies are available that correlate PP with aortic calcification at the segmental level. Methods: We identified 37 patients with aortic PP measured during cardiac catheterization. Their noncontrast chest computed tomography scans were evaluated for the presence of calcium in different segments (ascending aorta, arch of aorta [arch], descending aorta) and quantified. Patients with calcification (Calcified Group A) were compared against patients without calcification (Noncalcified Group B) in terms of PP, calcification and compliance. Results: The mean of the total calcium score was higher in the descending aorta than the arch or ascending aorta (691 vs 571 vs 131, respectively, P < 0.0001). PP had the strongest correlation with calcification in the descending aorta (r = 0.47, P = 0.004). Calcified Group A had a much higher PP than Noncalcified Group B, with the greatest difference in the descending aorta (20 mmHg, P < 0.0001), lesser in the ascending aorta (10 mmHg, P = 0.12) and the least in the arch (5 mmHg, P = 0.38). Calcified Group A patients also had much lower compliance than Noncalcified Group B patients, with the greatest difference among groups seen in the descending aorta (0.7 mL/mmHg, P = 0.002), followed by the ascending aorta, then arch. Conclusions: These are the first data to evaluate the relative impact of aortic segments in PP. Finding the greatest amount of calcification along with greatest change in PP and compliance in the descending aorta makes a case that the descending aorta plays a major role in PP as compared to other segments of the thoracic aorta. |
| Databáze: | OpenAIRE |
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