Non-immune Hemolysis in Gaucher Disease and Review of the Literature
Autor: | Najib Dally, Eliyakim Hershkop, Idan Bergman, Alina Kurolap, Hagit Baris Feldman |
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Rok vydání: | 2021 |
Předmět: |
Hemolytic anemia
Cytopenia education.field_of_study business.industry Anemia Population Hepatosplenomegaly General Medicine Gaucher disease medicine.disease Hemolysis medicine.anatomical_structure non-immune hemolytic anemia hemic and lymphatic diseases Enzyme replacement therapy Immunology medicine Bone marrow Clinical Case Report medicine.symptom education Bone pain business hemolytic anemia |
Zdroj: | Rambam Maimonides Medical Journal |
ISSN: | 2076-9172 |
Popis: | Gaucher disease (GD) is an autosomal recessive disease characterized by the buildup of glucocerebrosides in macrophages, resulting in the formation of “Gaucher cells.” These cells predominantly infiltrate the liver, spleen, and bone marrow leading to hepatosplenomegaly, cytopenia, and bone pain. Anemia in GD is typically considered to result from non-hemolytic processes. Although rare, a higher rate of hemolytic anemia of the autoimmune type has been reported in GD than in the general population. The literature on non-immune hemolytic anemia in GD is scarce. We review the literature on hemolytic anemia in GD and report on a case of non-immune hemolytic anemia secondary to GD. We believe this is the first description of a patient with confirmed GD and symptomatic non-immune hemolytic anemia that responded to GD-specific treatment. |
Databáze: | OpenAIRE |
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