Endocrine Influences on Ulceration and Regeneration in the Alkali-Burned Cornea
| Autor: | Cecil V. Crabb |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Medroxyprogesterone
medicine.medical_specialty Time Factors Indomethacin Alkalies Lesion Internal medicine Cornea Burns Chemical medicine Animals Medroxyprogesterone acetate Endocrine system Corneal Ulcer Wound Healing Chemistry Regeneration (biology) medicine.disease Adenosine eye diseases Epithelium Surgery Ophthalmology Endocrinology medicine.anatomical_structure Bucladesine Corneal neovascularization Rabbits sense organs medicine.symptom Corneal Injuries medicine.drug |
| Zdroj: | Archives of Ophthalmology. 95:1866-1870 |
| ISSN: | 0003-9950 |
| DOI: | 10.1001/archopht.1977.04450100168024 |
| Popis: | • Subconjunctival dibutyryl 3′,5′ cyclic adenosine monophosphoric acid (DBcAMP) produced a statistically significant reduction of ulceration in the alkaliburned rabbit cornea. No effect on epithelial cell growth was observed. DBcAMP also caused a statistically significant acceleration of corneal neovascularization in the first two weeks postburn. Medroxyprogesterone acetate also affected the development of corneal ulcers postalkali burn, but in a less well-defined manner. Dinoprost and indomethacin did not seem to influence this lesion. Cyclic adenosine monophosphoric acid may therefore possess a potential for use in the alkali-burned human eye. (Arch Ophthalmol95:1866-1870, 1977) |
| Databáze: | OpenAIRE |
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