Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahçeşehir (Istanbul) Breast Cancer Screening Project in Turkey
Autor: | Vahit Ozmen, Gülçin Vatandaş, Ömür Can, Gönül Aykuter, Sibel Özkan Gürdal, Nilufer Ozaydin, Cennet Sahin, Arda Kayhan, Beyza Ozcinar, Erkin Aribal, Neslihan Cabioglu |
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Přispěvatelé: | Acibadem University Dspace |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Oncology Risk Stage Cancer Research medicine.medical_specialty Turkey Turkish Population Expression Breast Neoplasms Carcinomas 03 medical and health sciences Breast cancer screening 0302 clinical medicine Age Internal medicine Original Reports Biomarkers Tumor Medicine Humans Mortality education Early Detection of Cancer education.field_of_study Program medicine.diagnostic_test business.industry Long term results Prognosis language.human_language 030104 developmental biology Impact 030220 oncology & carcinogenesis language Female business Biomarkers Mammography |
Zdroj: | JCO Global Oncology |
ISSN: | 2687-8941 |
Popis: | PURPOSE The Turkish Bahceehir Breast Cancer Screening Project was a 10-year, organized, population-based screening program carried out in Bahceehir county, Istanbul. Our aim was to examine the biologic features and outcome of screen-detected and interval breast cancers during the 10-year study period. METHODS Between 2009 and 2019, 2-view mammograms were obtained at 2-year intervals for women aged 40 to 69 years. Clinicopathological characteristics including ER, PR, HER2-neu, and Ki-67 status were analyzed for those diagnosed with breast cancer. RESULTS In 8,758 screened women, 131 breast cancers (1.5%) were detected. The majority of patients (82.3%) had prognostic stage 0-I disease. Contrarily, patients with interval cancers (n = 15; 11.4%) were more likely to have a worse prognostic stage (II-IV disease; odds ratio [OR], 3.59, 95% CI, 0.9 to 14.5) and high Ki-67 scores (OR, 3.14; 95% CI, 0.9 to 11.2). Interval cancers detected within 1 year were more likely to have a luminal B (57.1% v 31.9%) and triple-negative (14.3% v 1%) subtype and less likely to have a luminal A subtype (28.6% v 61.5%; P = .04). Patients with interval cancers had a poor outcome in 10-year disease-specific (DSS) and disease-free survival (DFS) compared with those with screen-detected cancers (DSS: 68.2% v 98.1%, P = .002; DFS: 78.6% v 96.5%, P = .011). CONCLUSION Our findings suggest the majority of screen-detected breast cancers exhibited a luminal A subtype profile with an excellent prognosis. However, interval cancers were more likely to have aggressive subtypes such as luminal B subtype or triple-negative cancers associated with a poor prognosis requiring other preventive strategies. (c) 2020 by American Society of Clinical Oncology RocheRoche Holding; Basaksehir (Basaksehir county in Istanbul) Municipality Supported by a grant from Roche (V.O.) and Basaksehir (Bahcesehir is a region in the Basaksehir county in Istanbul) Municipality. |
Databáze: | OpenAIRE |
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